{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:29Z","timestamp":1791500009921,"version":"4.3.4"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disordered proliferative endometrium is an under-recognized endometrial lesion,\n                    with limited evidence regarding its clinicopathological characteristics and\n                    predictors of treatment response. The present study aimed to characterize the\n                    clinical and histomorphological features of disordered proliferative\n                    endometrium, evaluate the response to treatment with a levonorgestrel-releasing\n                    intrauterine system, and identify the clinicopathological determinants of\n                    progesterone responsiveness. A 3-year cross-sectional study was conducted\n                    involving 124 women with histopathologically confirmed disordered proliferative\n                    endometrium. Clinical, demographic, radiological, and histopathological\n                    parameters were analysed, and the treatment response to the\n                    levonorgestrel-releasing intrauterine system was assessed after 3 months using\n                    pictorial blood assessment chart scores and symptom improvement. The median age\n                    at presentation was 42 years, with 59.7% of patients belonging to the\n                    perimenopausal age group (40\u201349 y). Heavy menstrual bleeding was the predominant\n                    presenting complaint (68.5%). Most patients were overweight or obese (64.5%),\n                    and 85.5% had anaemia. Hypertension (22.6%), hypothyroidism (13.7%), and\n                    diabetes mellitus (12.1%) were the most common associated comorbidities, while\n                    coexisting gynaecological pathologies were identified in 23.4% of cases.\n                    Histopathological examination consistently demonstrated focal glandular crowding\n                    and cystic glandular dilatation, with gland-to-stroma ratios ranging from 30:70\n                    to 60:40; an irregular glandular architecture was observed in 93.5% of cases.\n                    Following levonorgestrel-releasing intrauterine system insertion, 69.4% of\n                    patients experienced significant clinical improvement. A higher body mass index\n                    was the only independent predictor of reduced treatment response. Disordered\n                    proliferative endometrium predominantly affects perimenopausal women with heavy\n                    menstrual bleeding and metabolic risk factors, exhibits characteristic\n                    histomorphological features, and responds well to progesterone therapy in most\n                    cases. Recognition of factors influencing the treatment response may facilitate\n                    individualized management and improve clinical outcomes.<\/jats:p>","DOI":"10.1055\/a-2966-0186","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:42Z","timestamp":1791499242000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Profile of Disordered Proliferative Endometrium in Anovulatory Abnormal Uterine Bleeding and Determinants of Response to Levonorgestrel-Releasing Intrauterine System Therapy"],"prefix":"10.1055","author":[{"given":"Seetu","family":"Palo","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bibinagar, Telangana, India","place":["Hyderabad"],"department":["Department of Pathology and Laboratory Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0708-1037","authenticated-orcid":false,"given":"Mishu","family":"Mangla","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bibinagar, India","place":["Hyderabad"],"department":["Department of Obstetrics and Gynaecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Shekhar","family":"PRaja","sequence":"additional","affiliation":[{"name":"Clinova Diagnostics, India","place":["Hyderabad"],"department":["Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poojitha Kalyani","family":"Kanikaram","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bibinagar, India","place":["Hyderabad"],"department":["Department of Obstetrics and Gynaecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-6935","authenticated-orcid":false,"given":"Naina","family":"Kumar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bibinagar, India","place":["Hyderabad"],"department":["Department of Obstetrics and Gynaecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Mahaptra","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Bibinagar, Telangana, India","place":["Hyderabad"],"department":["Department of Pathology and Laboratory Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13224-016-0925-8","article-title":"FIGO\u2019s PALM-COEIN classification of abnormal uterine bleeding: A\n        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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2966-0186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:46Z","timestamp":1791499246000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2966-0186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1055\/a-2966-0186","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}