{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:52:03Z","timestamp":1791417123233,"version":"4.3.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thymectomy is established for myasthenia gravis (MG), but evidence from non-specialist general thoracic surgery units is limited. This study evaluates the feasibility and outcomes of thymectomy following an institutional transition from sternotomy to minimally invasive surgery, and assesses MG Composite and MG-ADL scores as longitudinal outcome measures.<\/jats:p>\n                  <jats:p>A single-center retrospective cohort study of 58 consecutive patients who underwent MG thymectomy between 2018 and 2026. The primary outcome was favorable clinical status (complete stable remission or improvement) at 1 year. Secondary outcomes included complications, length of stay, medication reduction, and changes in MG Composite score. Between-group comparisons across surgical approaches are descriptive and exploratory only.<\/jats:p>\n                  <jats:p>Surgical approaches were robotic-assisted thoracic surgery (RATS; n\u2009=\u200929; 50.0%), video-assisted thoracoscopic surgery (VATS; n\u2009=\u200922; 37.9%), and sternotomy (n\u2009=\u20097; 12.1%). Perioperative mortality was zero. Overall complication rate was 10.3%. A favorable outcome was achieved in 68.9% (95% CI: 57.3\u201381.9%). Sternotomy was associated with longer hospital stay (median 7 vs. 2\u20133 days; p\u2009=\u20090.02). Prednisolone and pyridostigmine were reduced or discontinued in 72.1 and 55.3% of preoperative users, respectively (both p\u2009&lt;\u20090.001). MG Composite and MG-ADL scores improved progressively from 3 months onward.<\/jats:p>\n                  <jats:p>Thymectomy can be safely and effectively performed in a general thoracic surgery unit with appropriate specialist input, achieving outcomes comparable to regional referral centers. Apparently, transition to minimally invasive surgery did not compromise safety or efficacy while significantly reducing hospital stay. Future studies should collect MG Composite and MG-ADL scores prospectively as standardized outcome measures.<\/jats:p>","DOI":"10.1055\/a-2969-6473","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:18:35Z","timestamp":1790637515000},"source":"Crossref","is-referenced-by-count":0,"title":["Minimally Invasive Thymectomy for Myasthenia Gravis: Feasibility and Functional Outcomes"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-6625","authenticated-orcid":false,"given":"Nicolas","family":"Mwesigwa","sequence":"additional","affiliation":[{"name":"St George's Hospital, United Kingdom","place":["London"],"department":["Department of Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulla","family":"Al-Shamari","sequence":"additional","affiliation":[{"name":"St George's University Hospitals NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samsul","family":"Islam","sequence":"additional","affiliation":[{"name":"St George's NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasnim","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"St George's NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"St George's NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Cardiothoracic Anaesthesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garcia-Reitboeck","sequence":"additional","affiliation":[{"name":"St George's NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Smelt","sequence":"additional","affiliation":[{"name":"St George's NHS Foundation Trust, United Kingdom","place":["London"],"department":["Department of Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrneurol.2016.44","article-title":"Myasthenia gravis\u2014autoantibody characteristics and their implications for therapy","volume":"12","author":"N E Gilhus","year":"2016","journal-title":"Nat Rev Neurol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/s12967-021-03185-7","article-title":"Global prevalence of myasthenia gravis and the effectiveness of common drugs in its treatment: a systematic review and meta-analysis","volume":"19","author":"N Salari","year":"2021","journal-title":"J Transl Med"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.47162\/RJME.62.1.07","article-title":"Thymus pathology in myasthenia gravis with anti-acetylcholine receptor antibodies and concomitant Hashimoto's thyroiditis. 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