{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:37:50Z","timestamp":1792712270029,"version":"4.5.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"Abstract<\/jats:title>\n To explore whether boundary-anchored apparent diffusion coefficient (ADC) profiling can characterize periventricular diffusion patterns in normal pressure hydrocephalus (NPH).<\/jats:p>\n Seventeen patients with shunted NPH with baseline and postoperative follow-up ADC maps acquired at 1.5 T or 3 T and 17 age-, sex-, and scanner-matched controls were analyzed retrospectively. A short anchor was placed along the frontal horn ventricular boundary. ADC values were sampled along approximately orthogonal lines and summarized as amplitude- and shape-related profile metrics. Patient-control and longitudinal within-patient comparisons were analyzed with false-discovery-rate correction for multiple comparisons.<\/jats:p>\n At baseline, patients showed a higher reference ADC, inner-zone mean ADC, outer-zone mean ADC, and outer plateau ADC than controls. At follow-up, amplitude-related ADC differences persisted. Longitudinally, the profile multiphasicity index, inner peak ADC, and initial profile slope changed after shunting and remained significant after FDR correction, whereas most amplitude-related metrics remained stable.<\/jats:p>\n Boundary-anchored ADC profiling identified persistent periventricular ADC differences and selected postoperative profile changes in NPH. The findings are exploratory and require validation.<\/jats:p>","DOI":"10.1055\/a-2970-7054","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:41:47Z","timestamp":1792708907000},"source":"Crossref","is-referenced-by-count":0,"title":["Spatially resolved periventricular ADC profiling in normal pressure hydrocephalus: an exploratory pilot study"],"prefix":"10.1055","author":[{"given":"Malvina","family":"Garner","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Fries","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Garner","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Hau\u00dfmann","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Reith","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-3575","authenticated-orcid":false,"given":"Umut","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2176\/nmc.st.2020-0292","article-title":"Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus","volume":"61","author":"M Nakajima","year":"2021","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/pn-2021-003291","article-title":"Idiopathic normal pressure hydrocephalus: historical context and a contemporary guide","volume":"23","author":"C Carswell","year":"2023","journal-title":"Pract Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1590\/1980-57642018dn13-020001","article-title":"Normal-pressure hydrocephalus: a critical review","volume":"13","author":"LM Oliveira","year":"2019","journal-title":"Dement Neuropsychol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.3390\/biomedicines11051265","article-title":"Imaging markers for normal pressure hydrocephalus: an overview","volume":"11","author":"ES Pyrgelis","year":"2023","journal-title":"Biomedicines"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1007\/s00330-020-07555-5","article-title":"Diagnostic performance and interobserver agreement of the callosal angle and Evans\u2019 index in idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis","volume":"31","author":"HY Park","year":"2021","journal-title":"Eur Radiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00701-022-05402-8","article-title":"Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis","volume":"165","author":"SG Thavarajasingam","year":"2023","journal-title":"Acta Neurochir (Wien)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0303-8467(03)00010-6","article-title":"Multi-modal MRI in normal pressure hydrocephalus identifies pre-operative haemodynamic and diffusion coefficient changes in normal appearing white matter correlating with surgical outcome","volume":"105","author":"RG Corkill","year":"2003","journal-title":"Clin Neurol Neurosurg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1177\/0284185113504570","article-title":"Effect of surgery on periventricular white matter in normal pressure hydrocephalus patients: comparison of two methods of DTI analysis","volume":"55","author":"B Nicot","year":"2014","journal-title":"Acta Radiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/1971400920975153","article-title":"The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: a literature review","volume":"34","author":"I Grazzini","year":"2021","journal-title":"Neuroradiol J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3174\/ajnr.A8108","article-title":"Prediction of surgical outcomes in normal pressure hydrocephalus by MR elastography","volume":"45","author":"P Karki","year":"2024","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neurad.2017.08.001","article-title":"Can MRI water apparent diffusion coefficient (ADC) value discriminate between idiopathic normal pressure hydrocephalus, Alzheimer\u2019s disease and subcortical vascular dementia?","volume":"45","author":"A Goujon","year":"2018","journal-title":"J Neuroradiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-7091-0923-6_6","article-title":"Changes of fractional anisotropy and apparent diffusion coefficient in patients with idiopathic normal pressure hydrocephalus","volume":"113","author":"K Demura","year":"2012","journal-title":"Acta Neurochir Suppl"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12987-016-0048-8","article-title":"A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study","volume":"14","author":"S Kanno","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12987-017-0072-3","article-title":"The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study","volume":"14","author":"F Tuniz","year":"2017","journal-title":"Fluids Barriers CNS"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2970-7054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:41:49Z","timestamp":1792708909000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2970-7054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1055\/a-2970-7054","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]}}}