{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:51:38Z","timestamp":1791849098246,"version":"4.3.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"Zusammenfassung<\/jats:title>\n Intraven\u00f6se Immunglobuline (IVIg) k\u00f6nnen vor\u00fcbergehende Autoantik\u00f6rperpositivit\u00e4t\n verursachen; ihre klinische Bedeutung bei Kindern ist jedoch unklar. Untersucht\n wurden H\u00e4ufigkeit und Verlauf post-IVIg nachweisbarer Autoantik\u00f6rper sowie ihr\n Zusammenhang mit sp\u00e4teren rheumatologischen Diagnosen.<\/jats:p>\n T1 wurde als die erste klinisch indizierte Autoantik\u00f6rperbestimmung innerhalb von 6\n Monaten nach IVIg definiert, T2 als die Folgeuntersuchung etwa 6 Monate nach IVIg.\n Antinukle\u00e4re Antik\u00f6rper (ANA) wurden mittels indirekter Immunfluoreszenz nach der\n Klassifikation des International Consensus on ANA Patterns (ICAP), extrahierbare\n nukle\u00e4re Antigene (ENA) mittels Immunoblot bestimmt.<\/jats:p>\n Von 205 Patienten waren 93 (45,4%) ANA-positiv. Sieben (3,4%) entwickelten eine\n rheumatologische Erkrankung (5 juveniler systemischer Lupus erythematodes, 1\n Dermatomyositis, 1 juvenile idiopathische Arthritis); alle geh\u00f6rten zur\n ANA-positiven Gruppe. Eine ENA-Positivit\u00e4t lag bei 60\/93 (64,5%) vor, am h\u00e4ufigsten\n f\u00fcr DFS70 (51,7%) und SSA\/Ro (35,0%). Von T1 zu T2 nahmen die ENA-Intensit\u00e4ten f\u00fcr\n DFS70, SSA\/Ro, Ro52, Histone, Nukleosomen, AMA-M2, dsDNA und Sm signifikant ab. Die\n ANA-Intensit\u00e4t war invers mit der Zeit seit IVIg assoziiert.<\/jats:p>\n Die meisten post-IVIg nachweisbaren ANA\/ENA-Positivit\u00e4ten bei Kindern scheinen\n vor\u00fcbergehend und klinisch stumm zu sein. Eine Wiederholung nach etwa 6 Monaten kann\n Fehlinterpretationen reduzieren; die weitere rheumatologische Abkl\u00e4rung sollte\n jedoch prim\u00e4r durch passende klinische Befunde und nicht allein durch eine\n persistierende Seropositivit\u00e4t geleitet werden.<\/jats:p>","DOI":"10.1055\/a-2970-7567","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:07:22Z","timestamp":1790723242000},"source":"Crossref","is-referenced-by-count":0,"title":["Autoantibody positivity and development of rheumatologic diseases\n in children receiving intravenous immunoglobulin therapy: a retrospective\n cohort study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-4028","authenticated-orcid":false,"given":"Halil","family":"Kazanasmaz","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University Faculty of\n Medicine, Turkey","place":["Trabzon"],"department":["Pediatric Rheumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-6953","authenticated-orcid":false,"given":"Firat","family":"Gundogmus","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University Faculty of\n Medicine, Turkey","place":["Trabzon"],"department":["Pediatric Rheumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3854-2410","authenticated-orcid":false,"given":"Ender Can","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University Faculty of\n Medicine, Turkey","place":["Trabzon"],"department":["Pediatric Rheumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukaddes","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University Faculty of\n Medicine, Turkey","place":["Trabzon"],"department":["Pediatric 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