{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:40:03Z","timestamp":1792453203098,"version":"4.5.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"ZUSAMMENFASSUNG<\/jats:title>\n Kernikterus ist eine gef\u00fcrchtete Komplikation des postnatalen\n Bilirubinanstiegs, der sich durch rechtzeitige Diagnose und Therapie\n vermeiden l\u00e4sst. Der Gipfel des Bilirubinanstiegs f\u00e4llt in eine Zeit, in der\n die Neugeborenen in der Regel im Anschluss an die U2 aus der\n Geburtseinrichtung entlassen sind, w\u00e4hrend die n\u00e4chste Vorsorgeuntersuchung\n U3 erst mehrere Wochen sp\u00e4ter ansteht.<\/jats:p>\n Evaluierung eines seit Ende 2010 bestehenden poststation\u00e4ren ambulanten\n Versorgungsangebots.<\/jats:p>\n Retrospektive Analyse der 2010\u20132024 in der Bilirubin-Ambulanz der Charit\u00e9\n vorgestellten Neugeborenen, aller im gleichen Zeitraum durchgef\u00fchrten\n Austauschtransfusionen, sowie exemplarisch von Einweisungen zu Fototherapien\n 2022.<\/jats:p>\n 2010\u20132016 wurden im Median j\u00e4hrlich 616 Neugeborene in der Bilirubin-Ambulanz\n vorgestellt, 2017\u20132024 1858 Neugeborene. Im Jahr 2022 wurden 6% der ambulant\n vorgestellten Neugeborenen zur Behandlung einer Hyperbilirubin\u00e4mie im\n medianen Alter von 6 [5\u20137] d station\u00e4r aufgenommen, mit einem\n Gesamtbilirubin von 20,5 [19,3\u201321,4] mg\/dl. Die beiden h\u00e4ufigsten\n Indikationen der 81 Austauschtransfusionen (78 Patienten) waren\n Rhesus-Unvertr\u00e4glichkeit (n=44; 56%) und neonatale H\u00e4mochromatose (n=24;\n 31%). Der Bilirubinwert unmittelbar vor Austauschtransfusion lag bei 15,5\n [12,5\u201320,0] mg\/dl (h\u00f6chster gemessener Wert 38,1\u2009mg\/dl).<\/jats:p>\n Die Versorgungsl\u00fccke im fr\u00fchen Wochenbett l\u00e4sst sich durch ein an die\n Neugeborenenstation angegliedertes ambulantes Angebot effektiv \u00fcberbr\u00fccken.\n Eine verbindliche U2a k\u00f6nnte die Nachsorge der neonatalen Hyperbilirubin\u00e4mie\n k\u00fcnftig standardisieren.<\/jats:p>","DOI":"10.1055\/a-2974-2741","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:54:58Z","timestamp":1792450498000},"source":"Crossref","is-referenced-by-count":0,"title":["Neonatale Hyperbilirubin\u00e4mie \u2013 \u00dcberbr\u00fcckung der Versorgungsl\u00fccke im\n fr\u00fchen Wochenbett"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-7176","authenticated-orcid":false,"given":"Sigrid","family":"Hahn","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany","place":["Berlin"],"department":["Neonatologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany","place":["Berlin"],"department":["Neonatologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Berns","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Germany","place":["Berlin"],"department":["Neonatologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1542\/neo.11-6-e316","article-title":"Core Concepts: bilirubin metabolism","volume":"11","author":"TW R 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bilirubin-induced\n neurologic dysfunction (BIND)","volume":"25","author":"S M Shapiro","year":"2005","journal-title":"J Perinatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.siny.2014.11.002","article-title":"Movement disorders due to bilirubin toxicity","volume":"20","author":"J Rose","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1542\/peds.103.1.6","article-title":"Predictive ability of a predischarge hour-specific serum bilirubin for\n subsequent significant hyperbilirubinemia in healthy term and near-term\n newborns","volume":"103","author":"V K Bhutani","year":"1999","journal-title":"Pediatrics."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa054244","article-title":"Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter\n or more","volume":"354","author":"T B Newman","year":"2006","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.clp.2004.05.001","article-title":"Understanding and preventing severe neonatal hyperbilirubinemia: is bilirubin\n neurotoxicity really a concern in the developed world?","volume":"31","author":"M Kaplan","year":"2004","journal-title":"Clin Perinatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.earlhumdev.2009.09.003","article-title":"Neonatal hyperbilirubinemia and kernicterus \u2013 not gone but sometimes\n forgotten","volume":"85","author":"M J Maisels","year":"2009","journal-title":"Early Hum Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1038\/jp.2008.212","article-title":"Kernicterus in the 21st century: frequently asked questions","volume":"29","author":"V K Bhutani","year":"2009","journal-title":"J Perinatol"},{"key":"ref17","first-page":"2026","article-title":"Kernicterus continues to occur in the USA despite concerted preventive\n efforts","author":"B B Zeiler","year":"2026","journal-title":"Case Rep Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e190858","DOI":"10.1001\/jamanetworkopen.2019.0858","article-title":"Rates of extreme neonatal hyperbilirubinemia and kernicterus in children and\n adherence to national guidelines for screening, diagnosis, and treatment in\n Sweden","volume":"2","author":"J Alk\u00e9n","year":"2019","journal-title":"JAMA Netw Open"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/jpc.16489","article-title":"Prospective cohort study of neurodevelopmental outcomes following extreme\n neonatal hyperbilirubinaemia in Australia","volume":"59","author":"A J McGillivray","year":"2023","journal-title":"J Paediatr Child Health"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/bfm.2017.29042.vjf","article-title":"ABM Clinical Protocol #22: Guidelines for management of jaundice in the\n breastfeeding infant 35 weeks or more of gestation \u2013 revised 2017","volume":"12","author":"Academy of Breastfeeding Medicine","year":"2017","journal-title":"Breastfeed Med"}],"container-title":["Klinische 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