{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:52:37Z","timestamp":1792785157047,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["140107\/2023-1,301638\/2026-8"],"award-info":[{"award-number":["140107\/2023-1,301638\/2026-8"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2024\/12893-4 ,2024\/14207-0 ,2025\/26016-8"],"award-info":[{"award-number":["2024\/12893-4 ,2024\/14207-0 ,2025\/26016-8"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"abstract":"<jats:p>To compare the time course of muscle hypertrophy during resistance training with progressive overload (PROG) or without overload progression (N-PROG), 31 healthy untrained young adults completed a randomized within-subject trial. Each participant trained one leg with PROG and the contralateral leg with N-PROG using unilateral knee extension (3x10\u201312 repetitions, twice weekly for 12 weeks). Load was progressively adjusted in PROG and kept constant in N-PROG. Muscle cross-sectional area (mCSA) was assessed at Pre and after sessions 6, 12, 18, and 24. A protocol\u00d7time interaction was observed for mCSA (p=0.002). Both protocols increased mCSA from Pre to S24 (PROG: 3.36\u00b11.94 cm\u00b2; N-PROG: 2.67\u00b11.86 cm\u00b2), with no significant between-protocol differences in mCSA at the individual assessment time points. However, the increase in mCSA from S18 to S24 was greater in PROG than in N-PROG (between-protocol difference in change: 1.22 cm\u00b2, 95% CI 0.59 to 1.84; p&lt;0.001). Repetitions in reserve (RIR) was 0.47\u00b10.61 at S1 and 0.20\u00b10.37 at S24 in PROG, and 1.50\u00b11.11 and 4.08\u00b11.94, respectively, in N-PROG. Overall volume load and perceived exertion were greater in PROG (p&lt;0.001). The PROG protocol maintained high relative effort, and the greater increase in mCSA compared with N-PROG was observed specifically from S18 to S24.<\/jats:p>","DOI":"10.1055\/a-2980-6473","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:56:23Z","timestamp":1792104983000},"source":"Crossref","is-referenced-by-count":0,"title":["Time course of muscle hypertrophy with and without progressive overload"],"prefix":"10.1055","author":[{"given":"Ot\u00e1vio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB \u2013 Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deivid G.","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio B. B.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o G. A.","family":"Bergamasco","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"Iasulaitis","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB \u2013 Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno K. R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C. C.","family":"Melo","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB \u2013 Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enya T. A.","family":"Nacafucasaco","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB \u2013 Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Rebelatto","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-7610","authenticated-orcid":false,"given":"Cleiton A.","family":"Libardi","sequence":"additional","affiliation":[{"name":"Federal University of Sao Carlos, SP, Brazil","place":["S\u00e3o Carlos"],"department":["MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education."]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2980-6473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:56:23Z","timestamp":1792104983000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2980-6473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1055\/a-2980-6473","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10,15]]},"published":{"date-parts":[[2026,10,15]]}}}