{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:45:31Z","timestamp":1791935131299,"version":"4.3.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:p>Background\nCoronary embolism (CE) is an uncommon cause of acute myocardial infarction, and the optimal post-discharge antithrombotic strategy remains uncertain.\nMethods \nRetrospective multicenter study including patients with definite or probable CE. Three groups of patients were identified: i) requiring with specific management, ii) with atrial fibrillation (AF), and iii) with no indication for oral anticoagulation (OAC). The latter two groups were further classified according to the antithrombotic treatment received, and long-term outcomes (composite of recurrent CE, stroke, systemic embolism, cardiovascular or all cause death and major bleeding at 5 years) were subsequently evaluated\nResults\nA total of 489 patients were considered. Among 189 patients with AF, 85 received direct oral anticoagulants (DOAC) and 104 vitamin K antagonists (VKAs). VKA users showed a higher rate of the composite endpoint compared with DOACs (40% vs. 18%, p &lt; 0.001) with the difference primarily driven by all-cause mortality. In multivariable analysis, VKA therapy remained independently associated with worse outcomes (HR 1.9, 95% CI 1.02\u20133.5; p=0.04). In the 182 patients without an indication for anticoagulation, 115 received antiplatelet therapy and 67 OAC. Those treated with OAC had a higher incidence of the composite outcome (16% vs. 7%, p=0.049) with the difference primarily driven by all-cause mortality. Multivariable analysis confirmed OAC as an independent predictor of adverse prognosis (HR 3.4 (95%CI 1.2-9.7;p=0.02).\nConclusions\nIn patients with CE, stratification based on underlying etiology and embolic risk before hospital discharge might serve as a decision-making approach for determining optimal antithrombotic strategies and improved clinical outcomes<\/jats:p>","DOI":"10.1055\/a-2980-6716","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:02:07Z","timestamp":1791932527000},"source":"Crossref","is-referenced-by-count":0,"title":["Antithrombotic Therapy in Coronary Embolism: A Multicenter Study"],"prefix":"10.1055","author":[{"given":"Alberto","family":"Vera","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa, Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Jover","sequence":"additional","affiliation":[{"name":"Navarrabiomed, Navarre, Spain","place":["Pamplona"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Varlot","sequence":"additional","affiliation":[{"name":"Nancy University Hospital Center, Grand Est, France","place":["Nancy"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Pozo-Osinalde","sequence":"additional","affiliation":[{"name":"Hospital Clinico San Carlos, Community of Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Vilches","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa, Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Ajo-Ferrer","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Juan de Alicante, Valencian Community, Spain","place":["Sant Joan d'Alacant"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Lanaspa","sequence":"additional","affiliation":[{"name":"Hospital de Navarra, Navarre, Spain","place":["Pamplona"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hospital de Navarra, Navarre, Spain","place":["Pamplona"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital Clinico San Carlos, Community of Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Jim\u00e9nez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Hospital Puerta del Mar, Spain","place":["C\u00e1diz"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rut","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias, Asturias, Spain","place":["Oviedo"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cuesta Margolles","sequence":"additional","affiliation":[{"name":"Hospital de Cabue\u00f1es, Asturias, Spain","place":["Gij\u00f3n"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Hospital Clinico San Carlos, Community of Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Ajo-Ferrer","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Dr Balmis, Valencian Community, Spain","place":["Alicante"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anai","family":"Moreno","sequence":"additional","affiliation":[{"name":"Hospital de Txagorritxu, PV, Spain","place":["Vitoria-Gasteiz"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlod","family":"Garc\u00eda-Filloy","sequence":"additional","affiliation":[{"name":"Bellvitge University Hospital, Spain","place":["L'Hospitalet de Llobregat"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancor","family":"Sanz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"University of Castilla-La Mancha - Talavera de la Reina Campus, Spain","place":["Toledo"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgina","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Hospital de Navarra, Navarre, Spain","place":["Pamplona"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa, Madrid, Spain","place":["Madrid"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriano","family":"Ruiz-Quevedo","sequence":"additional","affiliation":[{"name":"Hospital de Navarra, Navarre, Spain","place":["Pamplona"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batric","family":"Popovic","sequence":"additional","affiliation":[{"name":"Nancy University Hospital Center, Grand Est, France","place":["Nancy"],"department":["Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2980-6716.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:02:08Z","timestamp":1791932528000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2980-6716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1055\/a-2980-6716","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10,13]]},"published":{"date-parts":[[2026,10,13]]}}}