{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:00:03Z","timestamp":1769043603084,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Statins have marked beneficial effects on lipid profile, but also have pleiotropic actions. A previous study in an iodine-deficient area suggested that statin use is associated with reduced thyroid volume and nodularity. We performed this study to investigate how long-term statin use in type 2 diabetic patients affects thyroid nodularity in iodine-sufficient area.<\/jats:p><jats:p>We recruited euthyroid type 2 diabetic patients, receiving statin therapy continuously for at least 5 years (statin group) and, age and sex matched statin-naive type 2 diabetic patients (control group). Subjects with past history of cancer, thyroid disease or treatment with lithium or amiodarone; family history of thyroid cancer; palpable goiter or thyroid nodule, and\/or positive thyroperoxidase antibody were excluded. The prevalence, number, and volume of thyroid nodules, size of thyroid were evaluated in all subjects by high resolution ultrasound.<\/jats:p><jats:p>Prevalence of non-palpable thyroid nodules of statin group (n=70) and control group (n=98) were 51 and 53%\u2009, respectively. There was no difference of prevalence, number, and volume of non-palpable thyroid nodules and size of thyroid between statin and control group. But, the patients aged between 60 and 65 years from statin group showed lower prevalence of non-palpable thyroid nodules than the patients with same age interval from control group (4 out of 12 patients, 33%\u2009, statin group; 19 out of 27 patients, 70%\u2009, control group; P=0.04).<\/jats:p><jats:p>Long-term statin use in elderly type 2 diabetic patients was associated with lesser prevalence of thyroid nodules in an iodine-sufficient area. Our data might support a possible antiproliferative effect of statins on thyroid in old type 2 diabetic patients. But, the effect was not as strong as that in an iodine-deficient area and further studies with enough numbers of subjects and revised design will be needed.<\/jats:p>","DOI":"10.1055\/s-0031-1283123","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T01:09:39Z","timestamp":1315962579000},"page":"497-501","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Long-term Statin use in Type 2 Diabetic Patients on Thyroid Nodularity in Iodine-sufficient Area"],"prefix":"10.1055","volume":"119","author":[{"given":"M.","family":"Chon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Suk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2011,9,13]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0031-1283123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T14:43:25Z","timestamp":1691160205000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0031-1283123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2011,9,9]]},"published-print":{"date-parts":[[2011,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0031-1283123","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}