{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:24:53Z","timestamp":1783484693284,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is controversial whether screening program for thyroid disorders in pregnancy should be universal or targeted case-finding.<\/jats:p><jats:p>To evaluate the relationship between history, laboratory parameters and thyroid ultrasound (TUS) in pregnant women positive in universal screening.<\/jats:p><jats:p>The screening included investigation of serum TSH (thyroid stimulating hormone) and TPOAb (antithyroperoxidase antibodies) in 5\u2009520 unselected pregnant women in the 9\u201311th gestational week. In 822 the screening was positive: abnormal TSH (&gt;\u20093.67 or &lt;\u20090.06\u2009mIU\/l) and\/or positive TPOAb (&gt;\u2009143\u2009kIU\/l). 200 consecutive women with positive screening were included it the study.<\/jats:p><jats:p>41 women (21%) had transient gestational hyperthyroidism (TGH) and 159 (79%) had a thyroid pathology: 10 (5%) overt hypothyroidism; 76 (38%) subclinical hypothyroidism, 7 (3.5%) overt hyperthyroidism and 66 (33%) euthyroid TPOAb positivity. After exclusion of TGH, only 74\/159 (47%) women were classified as high-risk for thyroid disease according to their history. There were no significant clinical and laboratory differences between the high- vs. low-risk women, except for higher proportion of FT4&lt;75th percentile (P=0.008) and larger thyroid volume in the high-risk group (P=0.04). Finally, only 66\/126 (52%) of TPOAb-positive pregnant women had autoimmune pattern in TUS in comparison with 41\/49 (84%) TPOAb-positive non-pregnant control women of comparable age (P&lt;0.001).<\/jats:p><jats:p>Less than half of the positively screened pregnant women can be classified as high-risk and almost half of them had not autoimmune pattern in TUS. High- and low-risk pregnant women have similar clinical and laboratory characteristics.<\/jats:p>","DOI":"10.1055\/s-0031-1284369","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T01:30:04Z","timestamp":1312335004000},"page":"530-535","source":"Crossref","is-referenced-by-count":11,"title":["Low Prevalence of Clinically High-Risk Women and Pathological Thyroid Ultrasound among Pregnant Women Positive in Universal Screening for Thyroid Disorders"],"prefix":"10.1055","volume":"119","author":[{"given":"J.","family":"Jiskra","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bart\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160.","family":"Holinka","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"L\u00edmanov\u00e1","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Springer","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Anto\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Teli\u010dka","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Potlukov\u00e1","sequence":"additional","affiliation":[{"name":"3 rd Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2011,8,2]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0031-1284369.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T14:43:43Z","timestamp":1691160223000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0031-1284369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,2]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2011,10,17]]},"published-print":{"date-parts":[[2011,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0031-1284369","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,2]]}}}