{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:24:08Z","timestamp":1761823448902},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ectopic ACTH-syndrome is a rare cause of Cushing\u2019s disease. Despite extensive diagnostic procedures the source of ACTH secretion often remains occult.<\/jats:p><jats:p>This case describes a 45-year old woman with an ectopic Cushing\u2019s syndrome. Extensive imaging procedures including CT scan of chest and abdomen, octreotide scan and MRI of the chest and pituitary did not reveal the source of ACTH secretion.<\/jats:p><jats:p>In consideration of an occult source of ACTH secretion we started a therapeutic trial with cabergoline (0.5\u2009mg\/d), a dopamine receptor agonist, which has been shown to be effective in ectopic Cushing\u2019s syndrome. 2 months after cabergoline treatment had been initiated, ACTH and cortisol levels normalized in association with significant improvement of the clinical symptoms.<\/jats:p><jats:p>During follow-up a [68Ga-DOTA-dPhe1, Tyr3]-octreotate ([68Ga-DOTA]-TATE) PET-CT was performed revealing a somatostatin receptor positive lesion in the right sphenoidal sinus suggesting the source of ACTH secretion. The patient was cured by transnasal resection of the polypoid lesion, which was immunohistochemically characterized as an ACTH-positive neuroendocrine tumor.<\/jats:p><jats:p>This case report demonstrates the management of ectopic ACTH-syndrome by molecularly \u00adtargeted therapy with dopamine receptor \u00adagonists as well as improved detection of the ectopic ACTH source by novel imaging modalities, such as [68Ga-DOTA]-TATE PET specifically targeting somatostatin receptor subtype-2 with high affinity.<\/jats:p>","DOI":"10.1055\/s-0031-1297967","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:16:23Z","timestamp":1324426583000},"page":"63-67","source":"Crossref","is-referenced-by-count":18,"title":["An Unusual Case of Ectopic ACTH Syndrome"],"prefix":"10.1055","volume":"120","author":[{"given":"M.","family":"Willhauck","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine II of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"P\u00f6pperl","sequence":"additional","affiliation":[{"name":"Nuclear Medicine of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Rachinger","sequence":"additional","affiliation":[{"name":"Neurosurgery of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Giese","sequence":"additional","affiliation":[{"name":"Neuropathology of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Auernhammer","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine II of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Spitzweg","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine II of the Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2011,12,20]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0031-1297967.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T14:44:08Z","timestamp":1691160248000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0031-1297967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,20]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2012,2,9]]},"published-print":{"date-parts":[[2012,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0031-1297967","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,20]]}}}