{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:41:56Z","timestamp":1778575316831,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this meta-analysis was to evaluate the current best evidence to assess effectiveness and safety of recombinant human bone morphogenetic protein-7 (rhBMP-7) as a biological stimulant in spine fusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies were included if they reported on outcomes after spine fusion with rhBMP-7. The data was synthesized using Mantel-Haenszel pooled risk ratios (RRs) with 95% confidence intervals (CIs). Main end points were union rate, overall complications, postoperative back and leg pain, revision rates, and new-onset cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our search produced 796 studies, 6 of which were eligible for inclusion. These studies report on a total of 442 patients (328 experimental, 114 controls) with a mean age of 59\u2009\u00b1\u200911 years. Our analysis showed no statistically significant differences in union rates (RR 0.97, 95% CI 0.84 to 1.11, p\u2009=\u20090.247), overall complications (RR 0.92, 95% CI 0.71 to 1.20, p\u2009=\u20090.545), postoperative back and leg pain (RR 1.03, 95% CI 0.48 to 2.19, p\u2009=\u20090.941), or revision rate (RR 0.81, 95% CI 0.47 to 1.40, p\u2009=\u20090.449). There was a mathematical indicator of increased tumor rates, but with only one case, the clinical meaningfulness of this finding is questionable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We were not able to find data in support of the use of rhBMP-7 for spine fusion. We found no evidence for increased complication or revision rates with rhBMP-7. On the other hand, we also found no evidence in support of improved union rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1055\/s-0035-1557143","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:49:05Z","timestamp":1436899745000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Union Rate and Complications in Spine Fusion with Recombinant Human Bone Morphogenetic Protein-7: Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"6","author":[{"given":"Julia","family":"Vavken","sequence":"first","affiliation":[{"name":"Spine Unit, University Hospital of Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Vavken","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Center for Population and Development Studies, Harvard School of Public Health, Boston, Massachusetts, United States"},{"name":"Orthopaedic Department, University Hospital of Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Mameghani","sequence":"additional","affiliation":[{"name":"Spine Unit, University Hospital of Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schaeren","sequence":"additional","affiliation":[{"name":"Spine Unit, University Hospital of Basel, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"bibr1-s-0035-1557143","unstructured":"Landolfi A Bone and Soft Tissue Healing and Fusion Enhancement Products Proprietary Information of UnitedHealthcare 2014:1\u201330. 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