{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:31:03Z","timestamp":1790440263242,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine quality-of-life (QOL) outcomes for patients with lumbar spinal stenosis (LSS) treated with membrane-stabilizing agents (MSAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with LSS and concordant neurogenic claudication treated with MSAs ( n\u2009=\u2009701) or conservatively without MSAs ( n\u2009=\u20092104) at a single tertiary care hospital were identified. Patient QOL measures (Patient Health Questionnaire-9 [PHQ9], EuroQOL-5 Dimensions [EQ-5D], Pain Disability Questionnaire [PDQ]) were recorded pretreatment and then 4 months following treatment. Propensity score matching was used to account for baseline demographic differences between the two groups. The primary outcome measure was posttreatment improvement in these QOL measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in both groups had statistically significant improvements in the EQ-5D. However, the EQ-5D improvement in the MSA group was significantly greater than the improvement in the control group (0.11 versus 0.06; p\u2009=\u20090.0494). The EQ-5D change in the MSA group also exceeded the minimum clinically important difference, thereby suggesting a clinical significance. Both groups had significant pre- to posttreatment improvements in PDQ and PHQ-9, but these changes were not significantly different between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study suggest that patients with LSS and neurogenic claudication can have greater QOL improvements when treated with MSAs compared with other forms of conservative management without MSAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1055\/s-0035-1557144","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:49:05Z","timestamp":1436899745000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Membrane-Stabilizing Agents Improve Quality-of-Life Outcomes for Patients with Lumbar Stenosis"],"prefix":"10.1177","volume":"6","author":[{"given":"Sachin","family":"Bansal","sequence":"first","affiliation":[{"name":"Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lubelski","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Neurolgical Institute Center for Outcomes Research and Evaluation, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Good Shepherd Spine and Joint Center, Allentown, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Mazanec","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Benzel","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagreed","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Center for Spine Health, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"bibr1-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2009.03.005"},{"key":"bibr2-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1831"},{"key":"bibr3-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000261029.29170.e6"},{"key":"bibr4-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.50.1070"},{"key":"bibr5-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200103000-00007"},{"key":"bibr6-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-005-9005-0"},{"key":"bibr7-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"key":"bibr8-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106580"},{"key":"bibr9-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"bibr10-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199813040-00005"},{"key":"bibr11-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1137-x"},{"key":"bibr12-s-0035-1557144","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B2.21119"},{"key":"bibr13-s-0035-1557144","unstructured":"Wilson H Minimum Clinical Important Differences of Health Outcomes in a Chronic Pain Population: Are They Predictive of Poor Outcomes? 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