{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:01:35Z","timestamp":1790892095927,"version":"4.1.0"},"reference-count":67,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Iodine and selenium (Se) are both essential elements to thyroid hormone economy, while they represent key players in the development of autoimmune thyroiditis.<\/jats:p>\n                  <jats:p>Chronic high iodine intake has been associated in various studies with increased frequency of autoimmune thyroiditis. In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (TREG) cells development, while it triggers an abnormal expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction. As was shown in a mouse model, high iodine supply leads to changes in the immunogenicity of the thyroglobulin molecule, upregulation of vascular intercellular adhesion molecule-1 (ICAM-1), and reactive oxygen species (ROS) generation in the thyrocytes. Serum Se levels were found decreased in Hashimoto thyroiditis and especially in Graves\u2019 disease as well as in thyroid-associated ophthalmopathy patients, the levels being related to the pathogenesis and outcome. Selenium is strongly involved, via the variable selenoproteins, in antioxidant, redox, and anti-inflammatory processes. Selenium enhances CD4+\/CD25 FOXP3 and T regulatory cells activity while suppressing cytokine secretion, thus preventing apoptosis of the follicular cells and providing protection from thyroiditis. Selenium supplementation may be useful in autoimmune thyroid diseases, though, while usually well-tolerated, it should not be universally recommended, and it is also likely to be helpful for those with low Se status and autoimmunity. Broadly speaking, the achievement and maintenance of \u201cselenostasis\u201d as well as adequate urinary iodine excretion are mandatory to control disease, while, putatively, they may additionally be critical to preventing disease.<\/jats:p>","DOI":"10.1055\/s-0035-1559631","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T18:31:54Z","timestamp":1441996314000},"page":"721-726","source":"Crossref","is-referenced-by-count":91,"title":["The Role of Iodine and Selenium in Autoimmune Thyroiditis"],"prefix":"10.1055","volume":"47","author":[{"given":"L. H.","family":"Duntas","sequence":"additional","affiliation":[{"name":"Evgenidion Hospital, Thyroid Unit, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","author":"J G Hollowell","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/thy.1998.8.1179","article-title":"Epidemiology of thyroid diseases in iodine sufficiency","volume":"8","author":"P Lind","year":"1998","journal-title":"Thyroid"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1210\/jc.2002-020750","article-title":"Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake: a prospective comparative register-based population survey","volume":"87","author":"I B\u00fclow Pedersen","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpendmet0896","article-title":"Environmental factors and autoimmune thyroiditis","volume":"4","author":"L H Duntas","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jaut.2009.09.001","article-title":"Environmental triggers of autoimmune thyroiditis","volume":"33","author":"C L Burek","year":"2009","journal-title":"J Autoimmun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jaut.2011.04.002","article-title":"The genetics of autoimmune thyroiditis: the first decade","volume":"37","author":"N R Rose","year":"2011","journal-title":"J Autoimmun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ando.2011.03.019","article-title":"Environmental factors and thyroid autoimmunity","volume":"72","author":"L H Duntas","year":"2011","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-0029-1215568","article-title":"Thyroid autoimmunity and environment","volume":"41","author":"M L Tanda","year":"2009","journal-title":"Horm Metab Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12016-010-8245-8","article-title":"Cutting edge: the etiology of autoimmune thyroid diseases","volume":"41","author":"D C Eschler","year":"2011","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1089\/thy.2014.0182","article-title":"Impact of nutritional iodine optimization on rates of thyroid hypoechogenicity and autoimmune thyroiditis: a cross-sectional, comparative study","volume":"25","author":"D M Miranda","year":"2015","journal-title":"Thyroid"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2265.2011.04008.x","article-title":"A cautious iodization programme bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population","volume":"75","author":"I B Pedersen","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/EJE-08-0192","article-title":"Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil","volume":"159","author":"R Y Camargo","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2265.2011.04044.x","article-title":"Thyroid autoimmunity following an iodization programme","volume":"75","author":"M Vanderpump","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1530\/EJE-10-1041","article-title":"More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels","volume":"164","author":"X Teng","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/jc.2012-2960","article-title":"The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later","volume":"98","author":"F Aghini Lombardi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.beem.2009.08.013","article-title":"Iodine intake as a determinant of thyroid disorders in populations","volume":"24","author":"P Laurberg","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1210\/endo-118-5-1977","article-title":"The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB\/W rat","volume":"118","author":"E M Allen","year":"1986","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/clin.1996.0191","article-title":"Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice","volume":"81","author":"L Rasooly","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"ref19","first-page":"417","article-title":"Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extract","volume":"76","author":"N R Rose","year":"1956","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.14310\/horm.2002.1290","article-title":"Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis","volume":"10","author":"G Carayanniotis","year":"2011","journal-title":"Hormones"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"E1768","DOI":"10.1210\/jc.2013-2912","article-title":"Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin","volume":"98","author":"F Latrofa","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","first-page":"511","article-title":"The role of iodine in autoimmune thyroiditis","volume":"17","author":"N R Rose","year":"1997","journal-title":"Crit Rev Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14310\/horm.2002.1265","article-title":"Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis","volume":"9","author":"P Kolypetri","year":"2010","journal-title":"Hormones (Athens)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1677\/joe.0.1220185","article-title":"Expression of an intercellular adhesion molecule, ICAM-1, by human thyroid cells","volume":"122","author":"A P Weetman","year":"1989","journal-title":"J Endocrinol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.autrev.2008.04.006","article-title":"Autoimmune thyroiditis and ROS","volume":"7","author":"C L Burek","year":"2008","journal-title":"Autoimmun Rev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1089\/thy.2013.0142","article-title":"Differential regulation of the production of reactive oxygen species in Th1 cytokine-treated thyroid cells","volume":"24","author":"I M Colin","year":"2014","journal-title":"Thyroid"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.4049\/jimmunol.174.12.7740","article-title":"Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes","volume":"174","author":"R B Sharma","year":"2005","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nri702","article-title":"Cytokines and autoimmunity","volume":"2","author":"J J O\u2019Shea","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.4049\/jimmunol.170.11.5523","article-title":"Thyroid-specific expression of IFN-limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes","volume":"170","author":"J G Barin","year":"2003","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0952-7915(00)00228-4","article-title":"Signaling by type I and II cytokine receptors: ten years after","volume":"13","author":"M D Gadina","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1210\/en.2009-0434","article-title":"T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice","volume":"150","author":"I Horie","year":"2009","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1055\/s-0034-1382053","article-title":"IP-10 in autoimmune thyroiditis","volume":"46","author":"I Ruffilli","year":"2014","journal-title":"Horm Metab Res"},{"key":"ref33","first-page":"581069","article-title":"Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis","volume":"2014","author":"S L Cui","year":"2014","journal-title":"Int J Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.clim.2013.10.001","article-title":"Th17 cell plays a role in the pathogenesis of Hashimoto\u2019s thyroiditis in patients","volume":"149","author":"D Li","year":"2013","journal-title":"Clin Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12011-014-9958-y","article-title":"Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2h4 mice","volume":"159","author":"X Yang","year":"2014","journal-title":"Biol Trace Elem Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cei.12557","article-title":"Altered balance between self-reactive Th17 cells and Th10 cells and between full-length FOXP3 and FOXP3 splice variants in Hashimoto\u2019s thyroiditis","volume":"180","author":"B Kristensen","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jaut.2007.02.016","article-title":"The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts","volume":"28","author":"Y Ban","year":"2007","journal-title":"J Autoimmun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1089\/thy.2013.0495","article-title":"Enhanced iodine supplementation alters the immune process in a transgenic mouse model for autoimmune thyroiditis","volume":"24","author":"M Ehlers","year":"2014","journal-title":"Thyroid"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1089\/thy.2013.0676","article-title":"Apoptosis of NOD.H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress","volume":"24","author":"P Kolypetri","year":"2014","journal-title":"Thyroid"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1007\/s12011-010-8941-5","article-title":"TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice","volume":"143","author":"X Yu","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02917202","article-title":"Selenium concentrations in the human thyroid gland","volume":"24","author":"J Aaseth","year":"1990","journal-title":"Biol Trace Elem Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.1.05971","article-title":"Selenium and endocrine systems","volume":"184","author":"G J Beckett","year":"2005","journal-title":"J Endocrinol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1210\/jc.2010-0191","article-title":"Selenium and the thyroid: a close-knit connection","volume":"95","author":"L H Duntas","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1089\/thy.2009.0351","article-title":"Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis","volume":"20","author":"K A Toulis","year":"2010","journal-title":"Thyroid"},{"key":"ref45","first-page":"904573","article-title":"Selenium supplementation for autoimmune thyroiditis: a systematic review and meta-analysis","volume":"2014","author":"Y Fan","year":"2014","journal-title":"Int J Endocrinol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000356040","article-title":"Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review","volume":"3","author":"E J van Zuuren","year":"2014","journal-title":"Eur Thyroid J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s12020-014-0477-6","article-title":"Selenium: an element for life","volume":"48","author":"L H Duntas","year":"2015","journal-title":"Endocrine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1055\/s-0034-1377029","article-title":"Selenium levels in patients with autoimmune thyroiditis and controls in lower Austria","volume":"46","author":"I Wimmer","year":"2014","journal-title":"Horm Metab Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/cen.12185","article-title":"Serum selenium is low in newly diagnosed Graves\u2019 disease: a population-based study","volume":"79","author":"I B\u00fclow Pedersen","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/157340607780620662","article-title":"Serum selenium levels in patients with remission and relapse of graves\u2019 disease","volume":"3","author":"T Wertenbruch","year":"2007","journal-title":"Med Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/cen.12392","article-title":"Serum selenium status in Graves\u2019 disease with and without orbitopathy: a case-control study","volume":"80","author":"J J Khong","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa1012985","article-title":"Selenium and the course of mild Graves' orbitopathy. European Group on Graves\u2019 Orbitopathy","volume":"364","author":"C Marcocci","year":"2011","journal-title":"N Engl J Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3945\/jn.109.120725","article-title":"Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols","volume":"140","author":"F W Hoffmann","year":"2010","journal-title":"J Nutr"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00005-007-0036-4","article-title":"Mechanisms by which selenium influences immune responses","volume":"55","author":"P R Hoffmann","year":"2007","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2172-10-57","article-title":"Selenoproteins regulate macrophage invasiveness and extracellular matrix related gene expression","volume":"10","author":"B A Carlson","year":"2009","journal-title":"BMC Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1089\/ars.2011.4145","article-title":"The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities","volume":"16","author":"Z Huang","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/clin.1997.4431","article-title":"Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras","volume":"85","author":"M E Fisfalen 1","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2174\/1566524033479429","article-title":"Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease","volume":"3","author":"T Takahashi","year":"2003","journal-title":"Curr Mol Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1365-2249.2006.03303.x","article-title":"Depletion of CD4+CD25+ regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1*0301) transgenic class II-knock-out non-obese diabetic mice","volume":"147","author":"J C Flynn","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref61","first-page":"74635","article-title":"Effect of Selenium on HLA-DR expression of thyrocytes","author":"C Bal\u00e1zs","year":"2012","journal-title":"Autoimmune Dis"},{"key":"ref62","first-page":"920","article-title":"Selenium supplementation alleviates autoimmune thyroiditis by regulating expression of TH1\/TH2 cytokines","volume":"26","author":"L Tan","year":"2013","journal-title":"Biomed Environ Sci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1210\/jc.2010-2986","article-title":"The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto\u2019s thyroiditis","volume":"96","author":"R Krysiak","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"S Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref65","first-page":"5455","article-title":"Macrophage, lymphocyte and chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity","author":"M J Parnham","year":"1983","journal-title":"Int J Immunopharmacol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molimm.2011.09.001","article-title":"Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages","volume":"49","author":"B A Carlson","year":"2011","journal-title":"Mol Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1210\/jc.2013-3539","article-title":"A polymorphism in the promoter region of the selenoprotein S gene (SEPS1) contributes to Hashimoto\u2019s thyroiditis susceptibility","volume":"99","author":"L R Santos","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"S 03","key":"ref68","doi-asserted-by":"crossref","first-page":"iii91","DOI":"10.1136\/ard.2007.078535","article-title":"Regulatory T cells and toll-like receptors: regulating the regulators","volume":"66","author":"R Sutmuller","year":"2007","journal-title":"Ann Rheum Dis"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0035-1559631.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T11:52:36Z","timestamp":1748605956000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0035-1559631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":67,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,9,11]]},"published-print":{"date-parts":[[2015,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0035-1559631","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}