{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:53:57Z","timestamp":1789894437485,"version":"4.0.1"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bilateral adrenal hyperplasia currently accounts for up to 2 thirds of cases of\n                    primary aldosteronism. As such, it represents a major opportunity for targeted\n                    medical management as opposed to unilateral surgically correctable forms of the\n                    disease. Although the majority of cases of primary aldosteronism are sporadic,\n                    bilateral adrenal hyperplasia may occur in the context of familial\n                    hyperaldosteronism where it is associated with specific germline mutations. Over\n                    the past 5 years, impressive progress has been made in our understanding of the\n                    genetic basis underlying primary aldosteronism, allowing us to identify and\n                    characterize new familial forms of the disease and to understand the mechanisms\n                    involved in the formation of aldosterone producing adenoma. In contrast, our\n                    knowledge of the genetic contribution to the development of bilateral adrenal\n                    hyperplasia, and in a larger context, to renin and aldosterone levels in the\n                    general population, is still poor. This review summarizes our current knowledge\n                    on the genetics of bilateral adrenal hyperplasia and addresses some open\n                    questions to be addressed by future research. In particular, genome-wide\n                    association studies in large populations may provide clues to understanding the\n                    genetic susceptibility underlying the development of primary aldosteronism.<\/jats:p>","DOI":"10.1055\/s-0035-1565198","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T23:43:53Z","timestamp":1448581433000},"page":"947-952","source":"Crossref","is-referenced-by-count":15,"title":["Bilateral Idiopathic Adrenal Hyperplasia: Genetics and\n                    Beyond"],"prefix":"10.1055","volume":"47","author":[{"given":"F.","family":"Fernandes-Rosa","sequence":"first","affiliation":[{"name":"INSERM, UMRS 970, Paris Cardiovascular Research Center, Paris,\n                    France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris,\n                    France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges\n                    Pompidou, Service de G\u00e9n\u00e9tique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boulkroun","sequence":"first","affiliation":[{"name":"INSERM, UMRS 970, Paris Cardiovascular Research Center, Paris,\n                    France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris,\n                    France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Jeunemaitre","sequence":"first","affiliation":[{"name":"INSERM, UMRS 970, Paris Cardiovascular Research Center, Paris,\n                    France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris,\n                    France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges\n                    Pompidou, Service de G\u00e9n\u00e9tique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-C.","family":"Zennaro","sequence":"additional","affiliation":[{"name":"INSERM, UMRS 970, Paris Cardiovascular Research Center, Paris,\n                    France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris,\n                    France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges\n                    Pompidou, Service de G\u00e9n\u00e9tique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism:\n                    an endocrine society clinical practice guideline","volume":"93","author":"J W Funder","year":"2008","journal-title":"J Clin Endocrinol 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     blood pressure, renin, and aldosterone levels","volume":"56","author":"N van Leeuwen","year":"2010","journal-title":"Hypertension"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.110.158543","article-title":"Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary\n                    aldosteronism","volume":"56","author":"S Boulkroun","year":"2010","journal-title":"Hypertension"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"E1341","DOI":"10.1210\/jc.2013-4255","article-title":"Adrenal nodularity and somatic mutations in primary aldosteronism: one node is\n                    the culprit?","volume":"99","author":"T Dekkers","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"E4591","DOI":"10.1073\/pnas.1505529112","article-title":"Aldosterone-stimulating somatic gene mutations are common in normal adrenal\n                    glands","volume":"112","author":"K Nishimoto","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/en.2011-1205","article-title":"Aldosterone-producing adenoma formation in the adrenal cortex involves\n                    expression of stem\/progenitor cell markers","volume":"152","author":"S Boulkroun","year":"2011","journal-title":"Endocrinology"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0035-1565198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T23:51:12Z","timestamp":1645573872000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0035-1565198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":54,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2015,12,14]]},"published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0035-1565198","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}