{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:42:32Z","timestamp":1752673352071},"reference-count":91,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism (PA) is the most frequent cause of secondary arterial\n                        hypertension. Beyond its effects on intravascular volume and blood pressure,\n                        PA causes metabolic alterations and a higher cardiovascular morbidity, which\n                        is reduced by PA-directed therapy. Experimental studies demonstrated that\n                        mineralocorticoid excess may also influence mineral homeostasis. A role in\n                        cardiovascular disease has also been attributed to parathyroid hormone\n                        (PTH). Increasing evidence supports a bidirectional interaction between\n                        aldosterone and PTH.<\/jats:p><jats:p>Primary hyperparathyroidism is associated with arterial hypertension and an\n                        increased cardiovascular morbidity and mortality, which might be associated\n                        to higher aldosterone values; parathyreoidectomy results in lowered\n                        aldosterone and blood pressure levels. PA leads to secondary\n                        hyperparathyroidism, which is reversible by PA-directed therapy. A lower\n                        bone mineral density and a higher fracture rate were also shown to be\n                        reversible by PA-directed therapy. There is a suspicion of a bidirectional\n                        interaction between aldosterone and PTH, which might lead to a higher\n                        cardiovascular risk. There are more and more reports about coincident PA and\n                        primary hyperparathyroidism. From a pathophysiologic point of view this\n                        constellation is best characterized as tertiary hyperparathyroidism. Future\n                        aspects should further clarify the extent of these endocrine interactions\n                        and analyze the influence of this interplay on cardiovascular morbidity and\n                        mortality and bone health.<\/jats:p>","DOI":"10.1055\/s-0035-1565224","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:17:57Z","timestamp":1450138677000},"page":"994-999","source":"Crossref","is-referenced-by-count":13,"title":["Parathyroid Gland Function in Primary Aldosteronism"],"prefix":"10.1055","volume":"47","author":[{"given":"M.","family":"Bekeran","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reincke","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Asbach","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1,125\n                    hypertensive patients","volume":"48","author":"G P Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism:\n                    an endocrine society clinical practice guideline","volume":"93","author":"J W Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/HYPERTENSIONAHA.112.197111","article-title":"Observational study mortality in treated primary aldosteronism: the German\n                    Conn\u2019s registry","volume":"60","author":"M Reincke","year":"2012","journal-title":"Hypertension"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archinternmed.2007.33","article-title":"Cardiovascular outcomes in patients with primary aldosteronism after\n                    treatment","volume":"168","author":"C Catena","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary\n                    aldosteronism","volume":"45","author":"P Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"H2023","DOI":"10.1152\/ajpheart.00477.2004","article-title":"Loss of bone minerals and strength in rats with aldosteronism","volume":"287","author":"V S Chhokar","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000441-200507000-00001","article-title":"Bone loss in rats with aldosteronism","volume":"330","author":"A L Runyan","year":"2005","journal-title":"Am J Med Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jacc.2008.03.039","article-title":"Fracture risk in men with congestive heart failure risk reduction with\n                    spironolactone","volume":"52","author":"L D Carbone","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"E638","DOI":"10.1210\/jc.2012-4007","article-title":"Serum parathyroid hormone in relation to all-cause and cardiovascular mortality:\n                    the Hoorn study","volume":"98","author":"A J van Ballegooijen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2013.08.016","article-title":"Aldosterone and parathyroid hormone interactions as mediators of metabolic and\n                    cardiovascular disease","volume":"63","author":"A Tomaschitz","year":"2014","journal-title":"Metabolism"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/HYPERTENSIONAHA.113.02253","article-title":"Interplay between sodium and calcium regulatory hormones: a clinically relevant\n                    research field","volume":"63","author":"A Tomaschitz","year":"2014","journal-title":"Hypertension"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MED.0000000000000062","article-title":"Interactions between adrenal-regulatory and calcium-regulatory hormones in human\n                    health","volume":"21","author":"J M Brown","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/hr.2010.251","article-title":"Hyperparathyroidism, arterial hypertension and aortic stiffness: a possible\n                    bidirectional link between the adrenal cortex and the parathyroid glands that\n                    causes vascular damage?","volume":"34","author":"G P Rossi","year":"2011","journal-title":"Hypertens Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from\n                    bovine parathyroid","volume":"366","author":"E M Brown","year":"1993","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11427-014-4779-y","article-title":"The calcium sensing receptor: from calcium sensing to signaling","volume":"58","author":"C Zhang","year":"2015","journal-title":"Sci China Life Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"40922","DOI":"10.1074\/jbc.M111.265454","article-title":"Calcium-sensing receptor modulates cell adhesion and migration via\n                    integrins","volume":"286","author":"S Tharmalingam","year":"2011","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/ki.2008.490","article-title":"A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in\n                    uremia","volume":"75","author":"N Koleganova","year":"2009","journal-title":"Kidney Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00030.2003","article-title":"Control of aldosterone secretion: a model for convergence in cellular signaling\n                    pathways","volume":"84","author":"A Spat","year":"2004","journal-title":"Physiol Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fendo.2015.00095","article-title":"Molecular and cellular mechanisms of aldosterone producing adenoma\n                    development","volume":"6","author":"S Boulkroun","year":"2015","journal-title":"Front Endocrinol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1210\/jcem-56-3-572","article-title":"Four-parameter model of the sigmoidal relationship between parathyroid hormone\n                    release and extracellular calcium concentration in normal and abnormal\n                    parathyroid tissue","volume":"56","author":"E M Brown","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s00467-010-1565-3","article-title":"FGF23 and the parathyroid glands","volume":"25","author":"J Silver","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","article-title":"Extracellular calcium sensing and extracellular calcium signaling","volume":"81","author":"E M Brown","year":"2001","journal-title":"Physiol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.nutr.20.1.507","article-title":"The extracellular Ca2+-sensing receptor: central mediator of systemic calcium\n                    homeostasis","volume":"20","author":"E M Brown","year":"2000","journal-title":"Ann Rev Nutr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1447-0594.2012.00945.x","article-title":"High parathyroid hormone, but not low vitamin D concentrations, expose elderly\n                    inpatients to hypertension","volume":"13","author":"L Mateus-Hamdan","year":"2013","journal-title":"Geriatr Gerontol Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/HYPERTENSIONAHA.111.179135","article-title":"Vitamin D, parathyroid hormone, and sudden cardiac death: results from the\n                    Cardiovascular Health Study","volume":"58","author":"R Deo","year":"2011","journal-title":"Hypertension"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/eurheartj\/ehq109","article-title":"Parathyroid hormone level is associated with mortality and cardiovascular events\n                    in patients undergoing coronary angiography","volume":"31","author":"S Pilz","year":"2010","journal-title":"Eur Heart J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.108.808733","article-title":"Plasma parathyroid hormone and the risk of cardiovascular mortality in the\n                    community","volume":"119","author":"E Hagstrom","year":"2009","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10557-012-6378-0","article-title":"Parathyroid hormone, A crucial mediator of pathologic cardiac remodeling in\n                    aldosteronism","volume":"27","author":"M R Rutledge","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00395-008-0774-4","article-title":"Ischemic injury activates PTHrP and PTH1R expression in human ventricular\n                    cardiomyocytes","volume":"104","author":"G Monego","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pcad.2012.02.004","article-title":"Disturbances in calcium metabolism and cardiomyocyte necrosis: the role of\n                    calcitropic hormones","volume":"55","author":"J Yusuf","year":"2012","journal-title":"Prog Cardiovasc Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1365-2796.2002.00984.x","article-title":"Cardiovascular disease, hypertension and renal function in primary\n                    hyperparathyroidism","volume":"251","author":"G M Hedback","year":"2002","journal-title":"J Intern Med"},{"key":"ref32","first-page":"113","article-title":"Relationship between abnormal regulation of cytoplasmic calcium and elevated\n                    blood pressure in patients with primary hyperparathyroidism","volume":"8","author":"L Lind","year":"1994","journal-title":"J Hum Hypertens"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.jhh.1001907","article-title":"Ambulatory monitoring of blood pressure (AMBP) in patients with primary\n                    hyperparathyroidism","volume":"19","author":"C Letizia","year":"2005","journal-title":"J Hum Hypertens"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1067\/msy.2000.110240","article-title":"Left ventricular systolic and diastolic function and exercise testing in primary\n                    hyperparathyroidism-effects of parathyroidectomy","volume":"128","author":"I L Nilsson","year":"2000","journal-title":"Surgery"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00268-002-6541-z","article-title":"Cardiovascular events before and after surgery for primary\n                    hyperparathyroidism","volume":"27","author":"P Vestergaard","year":"2003","journal-title":"World J Surg"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2265.1999.00651.x","article-title":"Left ventricular hypertrophy in primary hyperparathyroidism. Effects of\n                    successful parathyroidectomy","volume":"50","author":"A Piovesan","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0039-6060(97)90285-3","article-title":"Time course of regression of left ventricular hypertrophy after successful\n                    parathyroidectomy","volume":"121","author":"T Stefenelli","year":"1997","journal-title":"Surgery"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2362.1998.00289.x","article-title":"Increased risk of death from primary hyperparathyroidism \u2013 an update","volume":"28","author":"G Hedback","year":"1998","journal-title":"Eur J Clin Invest"},{"issue":"S 02","key":"ref39","first-page":"N68","article-title":"Clinical presentation of primary hyperparathyroidism in Europe \u2013 nationwide\n                    cohort analysis on mortality from nonmalignant causes","volume":"17","author":"I L Nilsson","year":"2002","journal-title":"J Bone Miner Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2265.2010.03958.x","article-title":"A record linkage study of outcomes in patients with mild primary\n                    hyperparathyroidism: the parathyroid epidemiology and audit research study\n                    (PEARS)","volume":"75","author":"N Yu","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1097\/00004872-199715110-00011","article-title":"Relationship between serum parathyroid hormone levels in the elderly and 24\u2009h\n                    ambulatory blood pressures","volume":"15","author":"L Morfis","year":"1997","journal-title":"J Hypertens"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCULATIONAHA.111.081307","article-title":"Coronary microvascular dysfunction induced by primary hyperparathyroidism is\n                    restored after parathyroidectomy","volume":"126","author":"E Osto","year":"2012","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1210\/jc.2014-3949","article-title":"Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone\n                    system inhibitors: the multi-ethnic study of atherosclerosis","volume":"100","author":"J Brown","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1210\/jc.2013-3214","article-title":"A high aldosterone to Renin ratio is associated with high serum parathyroid\n                    hormone concentrations in the general population","volume":"99","author":"E Fischer","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ijcard.2015.03.062","article-title":"Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular\n                    mortality risk","volume":"184","author":"A Tomaschitz","year":"2015","journal-title":"Int J Cardiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.surg.2009.09.041","article-title":"Serum aldosterone is correlated positively to parathyroid hormone (PTH) levels\n                    in patients with primary hyperparathyroidism","volume":"146","author":"L Brunaud","year":"2009","journal-title":"Surgery"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1530\/eje.0.1380543","article-title":"The effect of surgical treatment on secondary hyperaldosteronism and relative\n                    hyperinsulinemia in primary hyperparathyroidism","volume":"138","author":"L Kovacs","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02563790","article-title":"Adrenal responses to subtotal parathyroidectomy for primary\n                    hyperparathyroidism","volume":"41","author":"R Pacifici","year":"1987","journal-title":"Calcif Tissue Int"},{"key":"ref49","first-page":"45","article-title":"Changes in plasma renin and aldosterone after parathyroidectomy in patients with\n                    hyperparathyroidism","volume":"132","author":"I Sotornik","year":"1993","journal-title":"Casopis Lekaru Ceskych"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0026-0495(99)90075-6","article-title":"Renin-angiotensin-aldosterone system in primary hyperparathyroidism before and\n                    after surgery","volume":"48","author":"G Bernini","year":"1999","journal-title":"Metabolism"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/00004872-198809000-00009","article-title":"Hormone, calcium and blood pressure relationships in primary\n                    hyperparathyroidism","volume":"6","author":"A M Richards","year":"1988","journal-title":"J Hypertens"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/cs0760289","article-title":"Hypertension and renal dysfunction in primary hyperparathyroidism: effect of\n                    parathyroidectomy","volume":"76","author":"A K Salahudeen","year":"1989","journal-title":"Clin Sci (Lond)"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/hr.2010.232","article-title":"Pulse wave velocity in primary hyperparathyroidism and effect of surgical\n                    therapy","volume":"34","author":"J Rosa","year":"2011","journal-title":"Hypertens Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1210\/jc.2004-1400","article-title":"Arterial stiffness in mild primary hyperparathyroidism","volume":"90","author":"M R Rubin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00223-010-9409-5","article-title":"Aldosterone and parathyroid hormone: a complex and clinically relevant\n                    relationship","volume":"87","author":"S Pilz","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1210\/jc.2011-2183","article-title":"Hyperparathyroidism in patients with primary aldosteronism: cross-sectional and\n                    interventional data from the GECOH study","volume":"97","author":"S Pilz","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6823-12-19","article-title":"Effect of eplerenone on parathyroid hormone levels in patients with primary\n                    hyperparathyroidism: a randomized, double-blind, placebo-controlled trial","volume":"12","author":"A Tomaschitz","year":"2012","journal-title":"BMC Endocr Disord"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0002-9343(85)90328-6","article-title":"Calcium metabolism and parathyroid function in primary aldosteronism","volume":"78","author":"L M Resnick","year":"1985","journal-title":"Am J Med"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/HJH.0b013e32834f0451","article-title":"Mild hyperparathyroidism: a novel surgically correctable feature of primary\n                    aldosteronism","volume":"30","author":"C Maniero","year":"2012","journal-title":"J Hypertens"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/0895-7061(95)00182-O","article-title":"Alterations of calcium metabolism and of parathyroid function in primary\n                    aldosteronism, and their reversal by spironolactone or by surgical removal of\n                    aldosterone-producing adenomas","volume":"8","author":"E Rossi","year":"1995","journal-title":"Am J Hypertens"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00198-013-2399-1","article-title":"Bone health and aldosterone excess","volume":"24","author":"L Ceccoli","year":"2013","journal-title":"Osteoporos Int"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/jbmr.1660","article-title":"Bone involvement in aldosteronism","volume":"27","author":"A S Salcuni","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/HYPERTENSIONAHA.112.195891","article-title":"Hyperparathyroidism can be useful in the identification of primary aldosteronism\n                    due to aldosterone-producing adenoma","volume":"60","author":"G P Rossi","year":"2012","journal-title":"Hypertension"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"E1035","DOI":"10.1210\/jc.2013-3789","article-title":"Age below 40 or a recently proposed clinical prediction score cannot bypass\n                    adrenal venous sampling in primary aldosteronism","volume":"99","author":"A Riester","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/HYPERTENSIONAHA.113.01910","article-title":"Human interventions to characterize novel relationships between the\n                    renin-angiotensin-aldosterone system and parathyroid hormone","volume":"63","author":"J M Brown","year":"2014","journal-title":"Hypertension"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1359\/jbmr.2001.16.8.1496","article-title":"Colocalization of glucocorticoid and mineralocorticoid receptors in human\n                    bone","volume":"16","author":"S Beavan","year":"2001","journal-title":"J Bone Miner Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/jbmr.333","article-title":"Identification of homogeneous genetic architecture of multiple genetically\n                    correlated traits by block clustering of genome-wide associations","volume":"26","author":"M Gupta","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/HYPERTENSIONAHA.111.173948","article-title":"Primary hyperparathyroidism with concurrent primary aldosteronism","volume":"58","author":"C Maniero","year":"2011","journal-title":"Hypertension"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1152\/ajpendo.2001.280.2.E209","article-title":"PTH and PTH-related peptide enhance steroid secretion from human adrenocortical\n                    cells","volume":"280","author":"G Mazzocchi","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref70","first-page":"309","article-title":"Enhancement of the stimulatory effect of calcium on aldosterone secretion by\n                    parathyroid hormone","volume":"20","author":"K Olgaard","year":"1994","journal-title":"Miner Electrolyte Metab"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1677\/joe.0.1120431","article-title":"Response of adrenal cells to parathyroid hormone stimulation","volume":"112","author":"J Rosenberg","year":"1987","journal-title":"J Endocrinol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1210\/endo-129-1-489","article-title":"Parathyroid hormone modulates angiotensin II-induced aldosterone secretion from\n                    the adrenal glomerulosa cell","volume":"129","author":"C M Isales","year":"1991","journal-title":"Endocrinology"},{"key":"ref73","first-page":"988","article-title":"Interrelationships between the renin-angiotensin-aldosterone and calcium\n                    homeostatic systems","volume":"75","author":"F D Grant","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"S 07","key":"ref74","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1097\/00004872-198900076-00092","article-title":"Aldosterone and pressor responses to angiotensin II in primary\n                    hyperparathyroidism","author":"F Fallo","year":"1989","journal-title":"J Hypertension"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/endo-129-3-1233","article-title":"Parathyroid hormone and calcium: interactions in the control of renin secretion\n                    in the isolated, nonfiltering rat kidney","volume":"129","author":"J J Helwig","year":"1991","journal-title":"Endocrinology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/cs0840011","article-title":"Stimulatory action of parathyroid hormone on renin secretion in vitro: a study\n                    using isolated rat kidney, isolated rabbit glomeruli and superfused dispersed\n                    rat juxtaglomerular cells","volume":"84","author":"C Saussine","year":"1993","journal-title":"Clin Sci (Lond)"},{"key":"ref77","first-page":"360","article-title":"Chronic continuous PTH infusion results in hypertension in normal subjects","volume":"2","author":"H N Hulter","year":"1986","journal-title":"J Clin Hypertens"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1210\/endo-113-3-1036","article-title":"Corticosteroidogenesis and adenosine 3\u2032, 5\u2032- monophosphate production by the\n                    amino-terminal (1\u201334) fragment of human parathyroid hormone in rat\n                    adrenocortical cells","volume":"113","author":"B Rafferty","year":"1983","journal-title":"Endocrinology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ki.1972.107","article-title":"Renal handling of calcium and phosphate during mineralocorticoid \u201cescape\u201d in\n                    man","volume":"2","author":"A Rastegar","year":"1972","journal-title":"Kidney Int"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0895-7061(97)00366-X","article-title":"Acute effects of intravenous sodium chloride load on calcium metabolism and on\n                    parathyroid function in patients with primary aldosteronism compared with\n                    subjects with essential hypertension","volume":"11","author":"E Rossi","year":"1998","journal-title":"Am J Hypertens"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/FJC.0b013e3181ed064f","article-title":"Congestive heart failure: where homeostasis begets dyshomeostasis","volume":"56","author":"G Kamalov","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1572-0241.1999.01094.x","article-title":"A rare combination consisting of primary hyperaldosteronism and glucagonoma","volume":"94","author":"H Abe","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref83","first-page":"e51","article-title":"Quiz page. Secondary hypertension with contralateral pheochromocytoma and\n                    aldosteronoma","volume":"46","author":"R F Berbarie","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"ref84","first-page":"564","article-title":"Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia\n                    type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11\n                    deoxyribonucleic acid markers, including the MEN1 locus","volume":"75","author":"A Beckers","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/pgmj.56.651.45","article-title":"Primary hyperparathyroidism in a patient with Conn\u2019s syndrome","volume":"56","author":"A Fertig","year":"1980","journal-title":"Postgrad Med J"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1210\/jcem-51-1-144","article-title":"Primary hyperparathyroidism: possible cause of primary hyperaldosteronism in a\n                    60-year-old woman","volume":"51","author":"A Barkan","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2169\/internalmedicine.43.310","article-title":"Primary hyperparathyroidism associatiated with aldosterone-producing\n                    adrenocortical adenoma and breast cancer: relation to MEN1 gene","volume":"43","author":"M Honda","year":"2004","journal-title":"Intern Med"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/ajh\/hpu102","article-title":"Secondary hypertension due to concomitant aldosterone-producing adenoma and\n                    parathyroid adenoma","volume":"28","author":"K Chau","year":"2015","journal-title":"Am J Hypertens"},{"key":"ref89","first-page":"910984","article-title":"A rare presentation of primary hyperparathyroidism with concurrent\n                    aldosterone-producing adrenal carcinoma","author":"M Molina-Ayala","year":"2015","journal-title":"Case Rep Endocrinol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.2169\/internalmedicine.52.8794","article-title":"Primary aldosteronism with concurrent primary hyperparathyroidism in a patient\n                    with arrhythmic disorders","volume":"52","author":"L Petramala","year":"2013","journal-title":"Intern Med"},{"key":"ref91","first-page":"971","article-title":"Primary aldosteronism with concurrent primary hyperparathyroidism: clinical case\n                    load in a single centre","volume":"19","author":"A Concistre","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0035-1565224.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T23:55:27Z","timestamp":1645574127000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0035-1565224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":91,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2015,12,14]]},"published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0035-1565224","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}