{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T19:40:01Z","timestamp":1721331601146},"reference-count":20,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"02","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder in women between menarche and menopause. Clinical hyperandrogenism is the most important diagnostic criterion of the syndrome, which manifests as hirsutism in 70% of cases. Hirsute carriers of PCOS have high cardiovascular risk. Lipid accumulation product (LAP) is an index for the evaluation of lipid accumulation in adults and the prediction of cardiovascular risk. The aim of this study was to evaluate the association between LAP and hirsutism in women with PCOS.<\/jats:p><jats:p>\n          Methods\u2003This was a cross-sectional observational study of a secondary database, which included 263 patients who had visited the Hyperandrogenism Outpatient Clinic from November 2009 to July 2014. The exclusion criteria were patients without Ferriman-Gallwey index (FGI) and\/or LAP data. We used the Rotterdam criteria for the diagnosis of PCOS. All patients underwent medical assessment followed by measurement and recording of anthropometric data and the laboratory tests for measurement of the following: thyroid-stimulating hormone, follicle-stimulating hormone, prolactin, total testosterone, sex hormone binding globulin, 17-\u03b1-hydroxyprogesterone (follicular phase), glycohemoglobin A1c, and basal insulin. In addition, the subjects underwent lipid profiling and oral glucose tolerance tests. Other laboratory measurements were determined according to clinical criteria. LAP and the homeostatic model assessment index (HOMA-IR) were calculated using the data obtained. We divided patients into two groups: the PCOS group with normal LAP (&lt; 34.5) and the PCOS group with altered LAP (&gt; 34.5) to compare the occurrence of hirsutism. For statistical analysis, we used SPSS Statistics for Windows\u00ae and Microsoft Excel programs, with descriptive (frequencies, percentages, means, and standard deviations) and comparative analyses (Student's t-test and Chi-square test). We considered relations significant when the p-value was\u2009\u2264\u20090.05.<\/jats:p><jats:p>\n          Results\u2003LAP was high in most patients (n\u2009=\u2009177; 67.3%) and the FGI indicated that 58.5% of the patients (n\u2009=\u2009154) had hirsutism. The analysis by LAP quartiles showed a positive correlation (p\u2009=\u20090.04) among patients with a high FGI and an upper quartile LAP (&gt; 79.5) when compared with those with LAP\u2009&lt;\u200929.0 (lower quartile).<\/jats:p><jats:p>\n          Conclusion\u2003This study demonstrated an association between high LAP and hirsutism. The FGI could represent a simple and low-cost tool to infer an increased cardiovascular risk in women with PCOS.<\/jats:p>","DOI":"10.1055\/s-0036-1571423","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T01:52:45Z","timestamp":1456365165000},"page":"071-076","source":"Crossref","is-referenced-by-count":1,"title":["Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome"],"prefix":"10.61622","volume":"38","author":[{"given":"Fl\u00e1via Ribeiro de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Sa\u00fade e Ecologia Humana \u2013 FASEH, Vespasiano, Brazil; Laboratory of Human Reproduction, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais \u2013 UFMG, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Bicalho","family":"Rezende","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00edcolas Figueiredo","family":"Faria","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s Ribeiro Gon\u00e7alves","family":"Dias","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Carlos Santos de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Undergraduate Medical Course, FASEH, Vespasiano, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luiza Lunardi","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine; Laboratory of Human Reproduction and Hyperandrogenism Outpatient Clinic, Hospital das Cl\u00ednicas, UFMG, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia","family":"C\u00e2ndido","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine; Hyperandrogenism Outpatient Clinic, Hospital das Cl\u00ednicas, UFMG, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"R Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum Reprod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mce.2012.10.029","article-title":"Longterm management of Polycystic Ovarian Syndrome (PCOS)","volume":"373","author":"G W Bates","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"W A March","year":"2010","journal-title":"Hum Reprod"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"201.e1","DOI":"10.1016\/j.ajog.2010.03.008","article-title":"The diagnosis of polycystic ovary syndrome in adolescents","volume":"203","author":"E Carmina","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1196\/annals.1365.011","article-title":"Ovarian and adrenal hyperandrogenism","volume":"1092","author":"E Carmina","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2133.2004.06058.x","article-title":"Self-reported skin morbidity in Oslo. 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through life","volume":"18","author":"E Diamanti-Kandarakis","year":"2012","journal-title":"Curr Pharm Des"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/humupd\/dmp024","article-title":"Visually scoring hirsutism","volume":"16","author":"B O Yildiz","year":"2010","journal-title":"Hum Reprod Update"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and 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