{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:12:56Z","timestamp":1762431176008},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n            Background\u2003This study analyzed the impact of visceral pleural invasion (VPI) on the disease-free survival (DFS) of patients with partly solid pulmonary adenocarcinoma sized 30\u2009mm or smaller.<\/jats:p><jats:p>\n            Method\u2003This is a retrospective study of 147 patients with surgically resected pathologic N0 pulmonary adenocarcinoma that had a partly solid appearance on preoperative computed tomography. All patients presented with tumors of size 30\u2009mm or smaller. The DFS rate was estimated using Kaplan\u2013Meier method. A multivariate analysis for prognostic factors was performed using the Cox proportional hazards regression model.<\/jats:p><jats:p>\n            Results\u2003VPI was found in 36 patients. The 5-year DFS in 111 patients without VPI (97.6%) was significantly higher than that in 36 patients with VPI (63%) (p\u2009&lt;\u20090.0001). Univariate analysis revealed three significant poor prognostic predictors: the presence of VPI, the presence of lymphovascular invasion, and the size of the solid component on computed tomography (&gt;20, \u226430 mm). According to the multivariate analysis, VPI was found to be a significant poor prognostic predictor (hazard ratio for DFS\u2009=\u20097.31, 95% confidence interval\u2009=\u20091.444\u201337.014, p\u2009=\u20090.016).<\/jats:p><jats:p>\n            Conclusion\u2003VPI is a significant predictor of poor prognosis for small-sized (\u226430 mm) partly solid lung adenocarcinoma. Therefore, upstaging of the T factor from T1 to T2 on the basis of VPI as described by the TNM staging system is mandatory regardless of ground-glass opacity in small lung adenocarcinoma.<\/jats:p>","DOI":"10.1055\/s-0036-1586757","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T18:36:07Z","timestamp":1471026967000},"page":"150-155","source":"Crossref","is-referenced-by-count":16,"title":["Visceral Pleural Invasion Is a Significant Prognostic Factor in Patients with Partly Solid Lung Adenocarcinoma Sized 30\u2009mm or Smaller"],"prefix":"10.1055","volume":"66","author":[{"given":"Yangki","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Medical Center, Daegu, The Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eungbae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Medical Center, Daegu, The Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2016,8,12]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1586757.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T18:32:05Z","timestamp":1520361125000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1586757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2018,3,6]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1586757","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,12]]}}}