{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:41:25Z","timestamp":1792172485173,"version":"4.4.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n            Introduction\u2003This study aims to assess the procedure-related complications and survival following fetoscopic endotracheal occlusion (FETO) for severe congenital diaphragmatic hernia.<\/jats:p><jats:p>\n            Materials and Methods\u2003A systematic review and meta-analysis of PubMed and Scopus database searching for FETO procedure in severe CDH (lung-to-head ratio [LHR]\u2009&lt;\u20091.0 and\/or observed\/expected LHR\u2009&lt;\u20090.26 and\u2009&gt;\u20091\/3 liver herniation) were performed. The relative risk was assessed and 95% confidence interval (CI) calculated. Procedure complications and survival were compared between FETO and randomized controlled trial (RCT) as well as observational case\u2013control studies.<\/jats:p><jats:p>\n            Results\u2003A total of 4,807 records were retrieved based on the title and abstracts, and 18 studies were eligible for statistical analysis (1 RCT and 17 observational case\u2013control studies). Relative risk (95% CI) comparing FETO and controls for premature rupture of membrane, preterm birth\u2009&lt;\u200932 weeks, preterm birth\u2009&lt;\u200937 weeks, survival at 30 days, and survival at 6 months were 1.7 (0.8\u20132.4), 7.3 (0.4\u2013134), 1.8 (0.8\u20133.9), 5.8 (1.5\u201322.9), and 10.5 (1.5\u201374.7), respectively. Mean difference (95% CI) for gestational age at delivery comparing FETO and controls was 1.8 (\u22123.1 to \u22120.5). All these outcomes showed a low level of evidence.<\/jats:p><jats:p>\n            Conclusion\u2003FETO procedure increased the neonatal survival at 30 days and 6 months; however, it presented a higher rate of premature rupture of membrane, preterm birth\u2009&lt;\u200937 weeks, and decreased the gestational age at delivery by 2 weeks. Nonetheless, the level of evidence is low for all these outcomes. We suggested a large international multicenter RCT to prove the real benefits of FETO.<\/jats:p>","DOI":"10.1055\/s-0036-1587331","type":"journal-article","created":{"date-parts":[[2016,8,14]],"date-time":"2016-08-14T22:30:28Z","timestamp":1471213828000},"page":"297-305","source":"Crossref","is-referenced-by-count":36,"title":["Procedure-Related Complications and Survival Following Fetoscopic Endotracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia: Systematic Review and Meta-Analysis in the FETO Era"],"prefix":"10.1055","volume":"27","author":[{"given":"Gabriele","family":"Tonni","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ribeir\u00e3o Preto School of Medicine, S\u00e3o Paulo University (FMRP-USP), Ribeir\u00e3o Preto-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Ruano","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Fetal Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2016,8,14]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1587331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:26:33Z","timestamp":1513671993000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1587331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,14]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,7,18]]},"published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1587331","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,14]]}}}