{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:40:10Z","timestamp":1789800010879,"version":"4.0.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n            Background\/Purpose\u2003Evaluating the long-term outcome of spontaneous intestinal perforation (SIP).<\/jats:p><jats:p>\n            Methods\u2003We studied all patients treated for SIP at our institution between January 1, 2005 and December 31, 2014.<\/jats:p><jats:p>\n            Results\u2003Twenty-three infants (13 males) with a median gestational age of 26 (range: 23\u201332) weeks and a median weight of 825 (range: 560\u20131,965) g composed this cohort. Seventeen (74%) infants had an extremely low birth weight (ELBW); nine (39%) infants were the result of multiple pregnancies.<\/jats:p><jats:p>Patent ductus arteriosus (PDA) was present in 16 (70%) infants. Cyclooxygenase inhibitors were administered in 12 (52%) infants.<\/jats:p><jats:p>Ten infants (seven males, 44%) were diagnosed with intraventricular hemorrhage (IVH), which was identified in the majority (8\/10) at a median of 9 (range: 1\u201311) days prior to the perforation.<\/jats:p><jats:p>All patients presented with pneumoperitoneum and underwent a laparotomy at a median age of 9 (range: 2\u201316) days. Twenty-one patients had an ileal perforation. A temporary stoma was placed in 21 patients, whereas two got primary anastomosis. Two (8.7%) male infants died. During the long-term follow-up period (median 6 years), six (five males) (26%) infants developed moderate to severe disabilities in combination with cerebral palsy. No surgical complications were observed.<\/jats:p><jats:p>\n            Conclusion\u2003The most important risk factor for SIP is ELBW (75%). The distal ileum is the most frequent site of perforation (88%). Approximately 40% develop IVH most often prior to the SIP. Moderate to severe neurologic disabilities are seen in more than a quarter of the children. Disability and mortality affect mostly the male sex. Long-term risks of surgical complications are very low.<\/jats:p>","DOI":"10.1055\/s-0036-1593990","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T19:07:03Z","timestamp":1479236823000},"page":"346-351","source":"Crossref","is-referenced-by-count":15,"title":["Spontaneous Intestinal Perforation: The Long-Term Outcome"],"prefix":"10.1055","volume":"27","author":[{"given":"Xiang-Nan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Statistics, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mou","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk","family":"Tam","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Houben","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2016,11,15]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1593990.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T03:26:47Z","timestamp":1513654007000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1593990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,7,18]]},"published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1593990","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}