{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:31:52Z","timestamp":1763105512795},"reference-count":24,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aims to give information about the relationship between different types of factor deficiencies and maternal\/obstetric outcomes.<\/jats:p><jats:p>\n          Methods\u2003We retrospectively reviewed the medical records of eight women with factor deficiency disorders. The demographic and clinical features of the patients after their last pregnancies were registered retrospectively.<\/jats:p><jats:p>\n          Results\u2003There were 29 pregnancies among the 8 patients. The spontaneous abortion rate was relatively high in two patients with factor XIII deficiency (80% and 57.1%) compared with the other factor deficiency groups. There were 16 births, which included 1 set of twins, and 2 deaths (1 stillbirth and 1 postpartum exitus occurred in the same patient). Intrauterine growth restriction was noted in five cases; four of these occurred in factor X deficiency cases. The mean decrease in hemoglobin level of all patients after birth was 1.7 g\/dL (range, 0.2\u20133.6 g\/dL). Red blood cell transfusion was required only in one case of factor XIII deficiency.<\/jats:p><jats:p>\n          Conclusions\u2003There is currently no consensus on the pregnancy management of women with factor deficiencies because of the limited knowledge due to the rarity of such disorders. Labor should be managed in a dedicated unit with a team consisting of an obstetrician, a hematologist, an anesthesiologist, a midwife, and a pediatrician to minimalize the complications.<\/jats:p>","DOI":"10.1055\/s-0036-1597927","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T23:40:32Z","timestamp":1486424432000},"page":"04-08","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Rare Bleeding Disorders during Pregnancy on Maternal and Fetal Outcomes: Review of 29 Pregnancies at a Single Center"],"prefix":"10.61622","volume":"39","author":[{"given":"Gokcen","family":"Orgul","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Aktoz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Sinan","family":"Beksac","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey"},{"name":"Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1365-2516.2009.01984.x","article-title":"Pregnancy and rare bleeding disorders","volume":"15","author":"R Kadir","year":"2009","journal-title":"Haemophilia"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2516.2006.01314.x","article-title":"The obstetric and gynaecological management of women with inherited bleeding disorders--review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors' 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02","key":"ref6","doi-asserted-by":"crossref","first-page":"ii75","DOI":"10.1093\/bja\/aev374","article-title":"Disorders of coagulation in pregnancy","volume":"115","author":"D Katz","year":"2015","journal-title":"Br J Anaesth"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1054\/blre.2002.0191","article-title":"Factor X deficiency","volume":"16","author":"J Uprichard","year":"2002","journal-title":"Blood Rev"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00404-009-1090-4","article-title":"Severe factor X deficiency in a twin pregnancy","volume":"281","author":"M S Beksa\u00e7","year":"2010","journal-title":"Arch Gynecol Obstet"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12098-012-0796-7","article-title":"Factor X deficiency: a rare cause of puberty menorrhagia","volume":"80","author":"V Singh","year":"2013","journal-title":"Indian J 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Scand"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1471-0528.2007.01296.x","article-title":"Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency","volume":"114","author":"B Myers","year":"2007","journal-title":"BJOG"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2516.2006.01287.x","article-title":"Pregnancy in women with congenital factor VII deficiency","volume":"12","author":"A A Kulkarni","year":"2006","journal-title":"Haemophilia"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/hae.12978","article-title":"Women with congenital factor VII deficiency: clinical phenotype and treatment options from two international studies","volume":"22","author":"M Napolitano","year":"2016","journal-title":"Haemophilia"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ejogrb.2003.12.026","article-title":"Factor VII deficiency and its treatment in delivery with recombinant factor VII","volume":"116","author":"B Pehlivanov","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-0029-1225765","article-title":"Factor XIII Deficiency","volume":"35","author":"M Karimi","year":"2009","journal-title":"Semin Thromb Hemost"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2174\/1389450054545953","article-title":"Congenital blood coagulation factor XIII deficiency and perinatal management","volume":"6","author":"A Ichinose","year":"2005","journal-title":"Curr Drug 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