{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:22:38Z","timestamp":1790702558196,"version":"4.1.0"},"reference-count":21,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"02","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n            Objective\u2003To evaluate the association of age at first sexual intercourse with the results of the cervicovaginal cytology.<\/jats:p><jats:p>\n            Study Design\u2003Observational analytical study about the prevalence of altered cervicovaginal cytology results in women aged between 18 and 34 years from a densely populated area in Brazil, during 10 years. The patients were stratified into 2 categories according to their age at first sexual intercourse (13\u201316 years and 17\u201324 years).<\/jats:p><jats:p>\n            Results\u2003From the total of 2,505,154 exams, 898,921 tests were in accordance with the inclusion criteria. Considering women with 4 years or less from the first sexual intercourse as a reference, those with 5 to 9 years and 10 years or more showed a higher prevalence of high-grade squamous intraepithelial lesions (HSILs). Women with an earlier onset of sexual intercourse (13\u201316 years) showed higher prevalence ratios for atypical squamous cells (ASC), low-grade squamous intraepithelial lesion (LSIL) and HSIL. The prevalence ratio for HSIL adjusted by age at diagnosis and by age at first sexual intercourse was higher only for women with an earlier onset of sexual intercourse.<\/jats:p><jats:p>\n            Conclusions\u2003The age of first sexual intercourse could be a variable that might qualify the selection among young women who are really at a higher risk for HSIL.<\/jats:p>","DOI":"10.1055\/s-0036-1597973","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:50:22Z","timestamp":1487893822000},"page":"080-085","source":"Crossref","is-referenced-by-count":9,"title":["Early Age at First Sexual Intercourse is Associated with Higher Prevalence of High-grade Squamous Intraepithelial Lesions (HSIL)"],"prefix":"10.61622","volume":"39","author":[{"given":"Jos\u00e9 C\u00e2ndido Caldeira","family":"Xavier-J\u00fanior","sequence":"additional","affiliation":[{"name":"Instituto de Patologia de Ara\u00e7atuba, Ara\u00e7atuba, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozany Mucha","family":"Dufloth","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Funda\u00e7\u00e3o Pio XII, Barretos, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diama Bhadra","family":"Vale","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Tavares de","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Zeferino","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejogrb.2007.08.020","article-title":"Cervical screening in under 25s: a high-risk young population","volume":"139","author":"F Bano","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI28607","article-title":"Prophylactic human papillomavirus vaccines","volume":"116","author":"D R Lowy","year":"2006","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"M Schiffman","year":"2007","journal-title":"Lancet"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.1866","article-title":"HPV-mediated cervical carcinogenesis: concepts and clinical implications","volume":"208","author":"P J Snijders","year":"2006","journal-title":"J Pathol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/bjc.2013.322","article-title":"Characteristics and screening history of women diagnosed with cervical cancer aged 20-29 years","volume":"109","author":"A Castanon","year":"2013","journal-title":"Br J Cancer"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/bjc.2014.65","article-title":"Benefits and harms of cervical screening from age 20 years compared with screening from age 25 years","volume":"110","author":"R Landy","year":"2014","journal-title":"Br J Cancer"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S1701-2163(16)35464-0","article-title":"Invasive cervical cancer incidence and mortality among canadian women aged 15 to 29 and the impact of screening","volume":"34","author":"C Popadiuk","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1503\/cmaj.121505","article-title":"Recommendations on screening for cervical cancer","volume":"185","author":"J Dickinson","year":"2013","journal-title":"CMAJ"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.bjc.6600974","article-title":"Benefit of cervical screening at different ages: evidence from the UK audit of screening histories","volume":"89","author":"P Sasieni","year":"2003","journal-title":"Br J Cancer"},{"key":"ref10","volume-title":"Brasil. Minist\u00e9rio da Sa\u00fade. Instituto Nacional de C\u00e2ncer. [Brazilian cervical cancer screening guidelines]","year":"2016"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ypmed.2013.06.026","article-title":"Inequalities in Pap smear screening for cervical cancer in Brazil","volume":"57","author":"J Mart\u00ednez-Mesa","year":"2013","journal-title":"Prev Med"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/cncy.21312","article-title":"High-grade squamous intraepithelial lesion in women aged <30 years has a prevalence pattern resembling low-grade squamous intraepithelial lesion","volume":"121","author":"D B Vale","year":"2013","journal-title":"Cancer Cytopathol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpag.2008.08.003","article-title":"Follow-up compliance of adolescents with cervical dysplasia in an inner-city population","volume":"22","author":"F N Campbell","year":"2009","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijgo.2015.01.016","article-title":"Results of screening for cervical cancer among pregnant and non-pregnant women in Brazil","volume":"130","author":"J CC Xavier-J\u00fanior","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13027-015-0011-3","article-title":"HPV infection and cervical neoplasia: associated risk factors","volume":"10","author":"A A Ribeiro","year":"2015","journal-title":"Infect Agent Cancer"},{"key":"ref17","volume-title":"The Bethesda System for reporting cervical cytology: definitions, criteria, and explanatory notes. 2nd ed","author":"D Solomon","year":"2005"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.1989.03430070079034","article-title":"The 1988 Bethesda System for reporting cervical\/vaginal cytological diagnoses","volume":"262","year":"1989","journal-title":"JAMA"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1002\/ijc.26250","article-title":"Time since first sexual intercourse and the risk of cervical cancer","volume":"130","author":"M Plummer","year":"2012","journal-title":"Int J Cancer"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/sj.bjc.6604974","article-title":"Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries","volume":"100","author":"K S Louie","year":"2009","journal-title":"Br J Cancer"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1309\/AJCPTGD94EVRSJCG","article-title":"American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer","volume":"137","author":"D Saslow","year":"2012","journal-title":"Am J Clin Pathol"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","article-title":"Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study","volume":"9","author":"M R McCredie","year":"2008","journal-title":"Lancet Oncol"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/early-age-at-first-sexual-intercourse-is-associated-with-higher-prevalence-of-high-grade-squamous-intraepithelial-lesions-hsil\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1597973.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T19:06:54Z","timestamp":1721329614000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1597973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":21,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2017,3,20]]},"published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1597973","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}