{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:35:17Z","timestamp":1790004917765,"version":"4.0.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n            Objective \u2003This retrospective cohort study examined the effect of birth order on neonatal morbidity and mortality in very preterm twins.<\/jats:p><jats:p>\n            Study Design\u2003Using 2005 to 2012 data from the Canadian Neonatal Network, very preterm twins born between 24 0\/7 and 32 6\/7 weeks of gestation were included. Odds of morbidity and mortality of second-born cotwins compared with first-born cotwins were examined by matched-pair analysis. Outcomes were neonatal death, severe brain injury (intraventricular hemorrhage grade 3 or 4 or persistent periventricular echogenicity), bronchopulmonary dysplasia, severe retinopathy of prematurity (ROP) (&gt; stage 2), necrotizing enterocolitis (\u2265 stage 2), and respiratory distress syndrome (RDS). Multivariable analysis was performed adjusting for confounders.<\/jats:p><jats:p>\n            Result\u2003There were 6,636 twins (3,318 pairs) included with a mean gestational age (GA) of 28.9 weeks. A higher rate of small for GA occurred in second-born twins (10 vs. 6%). Mortality was significantly lower for second-born twins (4.3 vs. 5.3%; adjusted odds ratio: 0.75; 95% confidence interval [CI]: 0.59\u20130.95). RDS (66 vs. 60%; adjusted odds ratio: 1.40; 95% CI: 1.29\u20131.52) and severe retinopathy (9 vs. 7%; adjusted odds ratio: 1.46; 95% CI: 1.07\u20132.01) were significantly higher in second-born twins.<\/jats:p><jats:p>\n            Conclusion\u2003Thus, while second-born twins had reduced odds of mortality, they also had increased odds of RDS and ROP.<\/jats:p>","DOI":"10.1055\/s-0037-1598255","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T23:53:09Z","timestamp":1487893989000},"page":"845-850","source":"Crossref","is-referenced-by-count":9,"title":["The Effect of Birth Order on Neonatal Morbidity and Mortality in Very Preterm Twins"],"prefix":"10.1055","volume":"34","author":[{"given":"Elad","family":"Mei-Dan","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre, North York General Hospital, Toronto, Ontario, Canada"},{"name":"Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Neonatology and Obstetrics and Gynaecology, Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakesh","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Neonatology and Obstetrics and Gynaecology, Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Neonatology and Obstetrics and Gynaecology, Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Canadian Neonatal Network Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,2,23]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1598255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:51:10Z","timestamp":1513669870000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1598255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2017,7,4]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1598255","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}