{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T14:26:17Z","timestamp":1744986377454},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n            Introduction\u2003Otitis Externa is common ear infection with a prevalence of 1%.<\/jats:p><jats:p>\n            Objective\u2003The objective of this study is to evaluate the clinical and microbiological efficacy and safety profile with oral ciprofloxacin in the external bacterial otitis (EBO) management.<\/jats:p><jats:p>\n            Methods\u2003This is a prospective observational study conducted with EBO outpatients referred to the otorhinolaryngology center in Moscow between March and August 2013. Our study included patients from two cohorts, acute external bacterial otitis (AEBO) - Group 1 - and exacerbation of chronic otitis externa (CEBO) - Group 2. We administered Ciprofloxacin 500\u2009mg twice daily with standard topical EBO treatment for up to 10 days. Patients underwent evaluation on study visit days 1, 3, 5, and 10 for the severity. Bacteriological examination of ear canal cultures took place on Day 1 and Day 10.<\/jats:p><jats:p>\n            Results\u2003We collected data from 60 EBO outpatients (AEBO: N\u2009=\u200930 and CEBO: N\u2009=\u200930). Swimming was the major risk factor associated with the disease in addition to the most common pathogenic organisms - Staphylococcus aureus and Pseudomonas aeruginosa. was We attained complete resolution of the inflammatory process in 28 (93%) and 27 (90%) patients in the AEBO and CEBO group, respectively. We confirmed this by microbiological test with almost complete eradication of the causative organisms. Overall, we observed good positive dynamics of ear canal with no major side effects.<\/jats:p><jats:p>\n            Conclusion\u2003We found that Ciprofloxacin 500\u2009mg, when administered orally twice daily for 7 to 10 days in otitis externa patients is clinically and microbiologically effective and comparatively safer than other antimicrobials.<\/jats:p>","DOI":"10.1055\/s-0037-1598648","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T18:43:45Z","timestamp":1487357025000},"page":"329-335","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Efficacy and Tolerability of Oral Ciprofloxacin used in the Comprehensive Treatment of External Bacterial Otitis: An Observational Prospective Study"],"prefix":"10.1055","volume":"21","author":[{"given":"Alexander","family":"Gurov","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Kriukov","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Kunelskaya","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Isotova","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgiy","family":"Shadrin","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliya","family":"Luchsheva","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav","family":"Yakimov","sequence":"additional","affiliation":[{"name":"The Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Garg","sequence":"additional","affiliation":[{"name":"Emerging Markets, Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Akku","sequence":"additional","affiliation":[{"name":"Emerging Markets, Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,2,17]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1598648.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:31:04Z","timestamp":1557156664000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1598648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,10,5]]},"published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1598648","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}