{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:21:33Z","timestamp":1774675293279,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n            Background\u2003Patent ductus arteriosus (PDA) is a common complication of prematurity and a risk factor for poor outcome. Infants undergoing surgical PDA ligation are at highest risk for neurodevelopmental injury. Autonomic dysfunction has been described in premature infants with PDA.<\/jats:p><jats:p>\n            Aim\u2003To interrogate the autonomic nervous system by analysis of advanced heart rate variability (HRV) metrics before and after surgical closure of the PDA.<\/jats:p><jats:p>\n            Study Design\u2003Prospective, observational study.<\/jats:p><jats:p>\n            Subjects\u2003Twenty-seven infants born before 28 weeks' gestation were included in this study.<\/jats:p><jats:p>\n            Methods\u2003Continuous electrocardiogram data were sampled at a rate of 125 Hz for a total of 6 hours before and 6 hours after 30 hours of surgical closure. HRV was determined by detrended fluctuation analysis to calculate the short and long root mean square (RMSL and RMSS) and \u03b1 components at two time scales (long and short).<\/jats:p><jats:p>\n            Results\u2003Gestational age (GA) was positively associated with RMSL, RMSS, and \u03b1S and was negatively associated with \u03b1L. There was no difference between RMSs, RMSL, \u03b1S, or \u03b1L before and after surgery; however, median heart rate was lower after surgery (p\u2009&lt;\u20090.01).<\/jats:p><jats:p>\n            Conclusion\u2003Advancing GA is highly associated with increasing HRV; however, surgical ligation does not affect HRV in the postoperative period.<\/jats:p>","DOI":"10.1055\/s-0037-1600127","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T23:49:18Z","timestamp":1489189758000},"page":"874-878","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Surgical Patent Ductus Arteriosus Closure on Autonomic Function in Premature Infants"],"prefix":"10.1055","volume":"34","author":[{"given":"Marina","family":"Metzler","sequence":"first","affiliation":[{"name":"Division of Fetal and Transitional Medicine, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedavalli","family":"Govindan","sequence":"first","affiliation":[{"name":"Division of Fetal and Transitional Medicine, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tareq","family":"Al-Shargabi","sequence":"first","affiliation":[{"name":"Division of Fetal and Transitional Medicine, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip","family":"Nath","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Surgery, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia"},{"name":"Division of Cardiology, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Massaro","sequence":"first","affiliation":[{"name":"Division of Neonatology, Children's National Health System, Washington, District of Columbia"},{"name":"Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia"},{"name":"Division of Biostatistics and Study Methodology, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adre","family":"duPlessis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia"},{"name":"Division of Fetal and Transitional Medicine, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Govindan","sequence":"first","affiliation":[{"name":"Division of Fetal and Transitional Medicine, Children's National Health System, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nickie","family":"Andescavage","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Children's National Health System, Washington, District of Columbia"},{"name":"Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,3,10]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1600127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:51:19Z","timestamp":1513669879000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1600127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2017,7,4]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1600127","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}