{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:14:14Z","timestamp":1766870054418},"reference-count":27,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"03","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n            Purpose\u2003To describe the frequencies of chromosomal abnormalities found in abortion material, and to observe its correlation to maternal age.<\/jats:p><jats:p>\n            Methods\u2003A retrospective study was conducted based on data obtained from the databank of a medical genetics laboratory in Belo Horizonte, MG, Brazil. A total of 884 results from products of conception analysis were included, 204 of which were analyzed by cytogenetics, and 680 by molecular biology based on quantitative fluorescence polymerase chain reaction (QF-PCR). The frequency of individual chromosomal aberrations and the relationship between the presence of anomalies and maternal age were also evaluated. <\/jats:p><jats:p>\n            Results\u2003The conventional cytogenetics technique was able to detect 52% of normal and 48% of abnormal results in the analyzed material. Quantitative fluorescence polymerase chain reaction revealed 60% of normal and 40% of abnormal results from the samples evaluated by this method. The presence of trisomy 15 was detected only by cytogenetics, as it was not included in the QF-PCR routine investigation in the laboratory. A significant increase in abnormal results was observed among women aged 35 years or older compared with younger women (p\u2009=\u20090.02).<\/jats:p><jats:p>\n            Conclusion\u2003Chromosomal aberrations are still a major cause of spontaneous abortion, and the conventional cytogenetics technique is efficient for miscarriage material analysis, but molecular methods such as QF-PCR are adequate complementary strategies to detect the major chromosomal anomalies, leading to technical reports with reliable results.<\/jats:p>","DOI":"10.1055\/s-0037-1600521","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T23:46:53Z","timestamp":1489621613000},"page":"110-114","source":"Crossref","is-referenced-by-count":10,"title":["Frequency of Chromosomal Abnormalities in Products of Conception"],"prefix":"10.61622","volume":"39","author":[{"given":"Carolina Maria Marques de","family":"Paula","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Human, Social and Health Sciences, Universidade FUMEC, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Gontijo","family":"Ramos","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Human, Social and Health Sciences, Universidade FUMEC, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena B. B. L. Martins da","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, C\u00f3don Biotechnology Laboratory, Belo Horizonte, MG, Brazil"},{"name":"Department of Cytogenetics, C\u00f3don Biotechnology Laboratory, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyntia Roberta Almeida","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, C\u00f3don Biotechnology Laboratory, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Abreu","family":"Coxir","sequence":"first","affiliation":[{"name":"Department of Cytogenetics, C\u00f3don Biotechnology Laboratory, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lect\u00edcia Firpe","family":"Penna","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Human, Social and Health Sciences, Universidade FUMEC, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Mesquita Alves","family":"Teles","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Human, Social and Health Sciences, Universidade FUMEC, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"ref1","volume-title":"Gloss\u00e1rio revisado da terminologia das T\u00e9cnicas de Reprodu\u00e7\u00e3o Assistida (TRA","author":"F Zegers-Hochschild","year":"2009"},{"issue":"06","key":"ref2","first-page":"681","article-title":"Cytogenetic analysis of material from spontaneous abortion","volume":"56","author":"D L Rolnik","year":"2010","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1067\/S0002-9378(03)00700-2","article-title":"The clinical use of 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