{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:41:11Z","timestamp":1792298471872,"version":"4.4.0"},"reference-count":65,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damage to the central nervous system is known to be multiple, and microcephaly is considered the tip of the iceberg. Microcephaly actually represents the epilogue of this infection's devastating process on the central nervous system of embryos and fetuses. As a result of central nervous system aggression by the ZIKV, this infection brings the possibility of arthrogryposis, dysphagia, deafness and visual impairment. All of these changes of varying severity directly or indirectly compromise the future life of these children, and are already considered a congenital syndrome linked to the ZIKV. Diagnosis is one of the main difficulties in the approach of this infection. Considering the clinical part, it has manifestations common to infections by the dengue virus and the chikungunya fever, varying only in subjective intensities. The most frequent clinical variables are rash, febrile state, non-purulent conjunctivitis and arthralgia, among others. In terms of laboratory resources, there are also limitations to the subsidiary diagnosis. Molecular biology tests are based on polymerase chain reaction (PCR) with reverse transcriptase (RT) action, since the ZIKV is a ribonucleic acid (RNA) virus. The RT-PCR shows serum or plasma positivity for a short period of time, no more than five days after the onset of the signs and symptoms. The ZIKV urine test is positive for a longer period, up to 14 days. There are still no reliable techniques for the serological diagnosis of this infection. If there are no complications (meningoencephalitis or Guillain-Barr\u00e9 syndrome), further examination is unnecessary to assess systemic impairment. However, evidence is needed to rule out other infections that also cause rashes, such as dengue, chikungunya, syphilis, toxoplasmosis, cytomegalovirus, rubella, and herpes. There is no specific antiviral therapy against ZIKV, and the therapeutic approach to infected pregnant women is limited to the use of antipyretics and analgesics. Anti-inflammatory drugs should be avoided until the diagnosis of dengue is discarded. There is no need to modify the schedule of prenatal visits for pregnant women infected by ZIKV, but it is necessary to guarantee three ultrasound examinations during pregnancy for low-risk pregnancies, and monthly for pregnant women with confirmed ZIKV infection. Vaginal delivery and natural breastfeeding are advised.<\/jats:p>","DOI":"10.1055\/s-0037-1603450","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T22:41:06Z","timestamp":1496443266000},"page":"235-248","source":"Crossref","is-referenced-by-count":49,"title":["Zika Virus Infection in Pregnant Women and Microcephaly"],"prefix":"10.61622","volume":"39","author":[{"given":"Geraldo","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Fernandes","family":"Moron","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Timerman","sequence":"additional","affiliation":[{"name":"Hospital Professor Edmundo Vasconcelos, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar Eduardo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Santo Andr\u00e9, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corintio","family":"Mariani Neto","sequence":"additional","affiliation":[{"name":"Hospital Maternidade Leonor Mendes de Barros, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gutemberg Le\u00e3o de","family":"Almeida Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heron","family":"Werner Junior","sequence":"additional","affiliation":[{"name":"Alta Excel\u00eancia Diagn\u00f3stica, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilka Flavia Barra do","family":"Esp\u00edrito Santo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Manaus, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Alfredo Piffero","family":"Steibel","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Bortoletti Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juvenal Barreto Borriello de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Consult\u00f3rio M\u00e9dico Juvenal Barreto Borriello de Andrade, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Burl\u00e1","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Marcelo Burl\u00e1, Rio de Janeiro, RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Felipe","family":"Silva de S\u00e1","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton Eduardo","family":"Busso","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C\u00e9sar","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Augusto","family":"Moreira de S\u00e1","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Niter\u00f3i, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Passini Junior","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosiane","family":"Mattar","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana Pulcineli Vieira","family":"Francisco","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"ref2","volume-title":"Rapid risk assessment: Microcephaly in Brazil potentially linked to the Zika virus epidemic, 2015","year":"2015"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"J Mlakar","year":"2016","journal-title":"N Engl J Med"},{"issue":"20","key":"ref5","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika Virus and Birth defects\u2013Reviewing the Evidence for Causality","volume":"374","author":"S A Rasmussen","year":"2016","journal-title":"N Engl J Med"},{"key":"ref7","volume-title":"Secretaria de Estado da Sa\u00fade, Coordenadoria de Controle de Doen\u00e7as Centro de Vigil\u00e2ncia Epidemiol\u00f3gica, Instituto Adolfo Lutz. Vigil\u00e2ncia das microcefalias relacionadas \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.micinf.2015.12.010","article-title":"Zika and microcephaly: causation, correlation, or coincidence?","volume":"18","author":"J A Tetro","year":"2016","journal-title":"Microbes Infect"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15585\/mmwr.mm6503e2","article-title":"Brazilian Medical Genetics Society-Zika Embryopathy Task Force. Possible association between Zika virus infection and microcephaly - Brazil, 2015","volume":"65","author":"L Schuler-Faccini","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref10","first-page":"26","article-title":"Infec\u00e7\u00e3o pelo v\u00edrus zika durante a gravidez","volume":"44","author":"G Duarte","year":"2016","journal-title":"Femina"},{"key":"ref11","volume-title":"Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis. Protocolo de vigil\u00e2ncia e resposta \u00e0 ocorr\u00eancia de microcefalia e\/ou altera\u00e7\u00f5es do sistema nervoso central (SNC). Vers\u00e3o 2","year":"2016"},{"key":"ref12","volume-title":"Secretaria de Estado da Sa\u00fade. Centro de Vigil\u00e2ncia Epidemiol\u00f3gica da SESP-SP. Protocolo de vigil\u00e2ncia para gestantes com exantema","year":"2016"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.15585\/mmwr.mm6511e3","article-title":"Preventing transmission of zika virus in labor and delivery settings through implementation of standard precautions - United States, 2016","volume":"65","author":"C K Olson","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref15","volume-title":"Pregnancy management in the context of Zika virus. Interim guidance uptodate","year":"2016"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JVI.72.1.73-83.1998","article-title":"Phylogeny of the genus Flavivirus","volume":"72","author":"G Kuno","year":"1998","journal-title":"J Virol"},{"issue":"08","key":"ref18","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.3390\/v7082837","article-title":"Flaviviral Replication Complex: Coordination between RNA Synthesis and 5'-RNA Capping","volume":"7","author":"V J Klema","year":"2015","journal-title":"Viruses"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"G W Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10900-016-0177-7","article-title":"The convergence of a virus, mosquitoes, and human travel in globalizing the zika epidemic","volume":"41","author":"P J Imperato","year":"2016","journal-title":"J Community Health"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(16)00003-9","article-title":"Zika virus genome from the Americas","volume":"387","author":"A Enfissi","year":"2016","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: Early epidemiological and genetic findings","volume":"352","author":"N R Faria","year":"2016","journal-title":"Science"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3201\/eid2210.160663","article-title":"Distinct zika virus lineage in Salvador, Bahia, Brazil","volume":"22","author":"S N Naccache","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"09","key":"ref25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy\u2013Brazil, 2015","volume":"65","author":"W Kleber de Oliveira","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0140-6736(15)61273-9","article-title":"Zika virus: following the path of dengue and chikungunya?","volume":"386","author":"D Musso","year":"2015","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation","volume":"388","author":"G V Fran\u00e7a","year":"2016","journal-title":"Lancet"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2105\/AJPH.2016.303115","article-title":"Initial Description of the Presumed Congenital Zika Syndrome","volume":"106","author":"DdeB Miranda-Filho","year":"2016","journal-title":"Am J Public Health"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamaophthalmol.2016.0267","article-title":"Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil","volume":"134","author":"B de Paula Freitas","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.15585\/mmwr.mm6512e3","article-title":"Update: Interim Guidance for Prevention of Sexual Transmission of Zika Virus\u2013United States, 2016","volume":"65","author":"A M Oster","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"39","key":"ref31","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.15585\/mmwr.mm6539e1","article-title":"Update: Interim guidance for preconception counseling and prevention of sexual transmission of zika virus for persons with possible zika virus exposure \u2013 United States, September 2016","volume":"65","author":"E E Petersen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"04","key":"ref33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tmaid.2016.07.002","article-title":"Non-vector-borne transmission of Zika virus: A systematic review","volume":"14","author":"F Grischott","year":"2016","journal-title":"Travel Med Infect Dis"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/ajt.14047","article-title":"Zika virus infection and solid organ transplantation: A new challenge","volume":"17","author":"M L Nogueira","year":"2017","journal-title":"Am J Transplant"},{"issue":"14","key":"ref35","doi-asserted-by":"crossref","first-page":"20761","DOI":"10.2807\/1560-7917.ES2014.19.14.20761","article-title":"Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014","volume":"19","author":"D Musso","year":"2014","journal-title":"Euro Surveill"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/genomeA.00032-16","article-title":"First complete genome sequence of Zika virus (Flaviviridae, Flavivirus) from an autochthonous transmission in Brazil","volume":"4","author":"M S Cunha","year":"2016","journal-title":"Genome Announc"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3201\/eid2112.151167","article-title":"Outbreak of exanthematous illness associated with Zika, Chikungunya, and Dengue viruses, Salvador, Brazil","volume":"21","author":"C W Cardoso","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"24","key":"ref38","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"M R Duffy","year":"2009","journal-title":"N Engl J Med"},{"key":"ref39","volume-title":"Flaviviruses","author":"T C Piersen","year":"2013"},{"issue":"18","key":"ref40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.15585\/mmwr.mm6518e1","article-title":"Interim guidance for zika virus testing of urine - United States, 2016","volume":"65","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"09","key":"ref43","doi-asserted-by":"crossref","first-page":"20720","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013","volume":"19","author":"E Oehler","year":"2014","journal-title":"Euro Surveill"},{"issue":"02","key":"ref44","first-page":"391","article-title":"[Aedes aegypti control strategies: a review]","volume":"25","author":"A L Zara","year":"2016","journal-title":"Epidemiol Serv Saude"},{"key":"ref47","volume-title":"Birth Defects Surveillance: A Manual for Programme Managers","year":"2014"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(14)61490-2","article-title":"International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project","volume":"384","author":"A T Papageorghiou","year":"2014","journal-title":"Lancet"},{"key":"ref50","volume-title":"Assessment of infants with microcephaly in the context of Zika virus. Interim guidance","year":"2016"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/uog.15896","article-title":"ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals","volume":"47","author":"A T Papageorghiou","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"11","key":"ref52","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/WNL.0b013e3181b783f7","article-title":"Practice parameter: Evaluation of the child with microcephaly (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society","volume":"73","author":"S Ashwal","year":"2009","journal-title":"Neurology"},{"issue":"05","key":"ref53","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure","volume":"165","author":"X Qian","year":"2016","journal-title":"Cell"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.2016.19006","article-title":"Birth defects among fetuses and infants of US women with evidence of possible zika virus infection during pregnancy","volume":"317","author":"M A Honein","year":"2017","journal-title":"JAMA"},{"issue":"06","key":"ref55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0036-1584206","article-title":"Challenges of Zika Virus Infection in Pregnant Women","volume":"38","author":"G Duarte","year":"2016","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"01","key":"ref56","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/uog.15831","article-title":"Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?","volume":"47","author":"A S Oliveira Melo","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"26","key":"ref57","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1056\/NEJMc1607580","article-title":"Prolonged zika virus viremia during pregnancy","volume":"375","author":"A Suy","year":"2016","journal-title":"N Engl J Med"},{"issue":"03","key":"ref58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.spen.2007.07.003","article-title":"Microcephaly syndromes","volume":"14","author":"D Abuelo","year":"2007","journal-title":"Semin Pediatr Neurol"},{"issue":"04","key":"ref59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/01.ruq.0000187025.61943.ff","article-title":"Ultrasound markers of fetal infection part 1: viral infections","volume":"21","author":"L A Bail\u00e3o","year":"2005","journal-title":"Ultrasound Q"},{"issue":"06","key":"ref60","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/uog.15894","article-title":"Ultrasound-based gestational-age estimation in late pregnancy","volume":"48","author":"A T Papageorghiou","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"05","key":"ref61","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/uog.15801","article-title":"Prediction of microcephaly at birth using three reference ranges for fetal head circumference: can we improve prenatal diagnosis?","volume":"47","author":"Z Leibovitz","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"T R Fenton","year":"2013","journal-title":"BMC Pediatr"},{"issue":"05","key":"ref63","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0002-9378(84)90027-9","article-title":"The diagnosis of fetal microcephaly","volume":"149","author":"F A Chervenak","year":"1984","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref64","first-page":"908","article-title":"A prospective study of the accuracy of ultrasound in predicting fetal microcephaly","volume":"69","author":"F A Chervenak","year":"1987","journal-title":"Obstet Gynecol"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"e681","DOI":"10.1016\/S2214-109X(15)00163-1","article-title":"Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21(st) Project","volume":"3","author":"J Villar","year":"2015","journal-title":"Lancet Glob Health"},{"issue":"12","key":"ref66","doi-asserted-by":"crossref","first-page":"315","DOI":"10.15585\/mmwr.mm6512e2","article-title":"Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure \u2013 United States, 2016","volume":"65","author":"E E Petersen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"04","key":"ref67","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3201\/eid2304.161692","article-title":"Presence and persistence of zika virus RNA in semen, United Kingdom, 2016","volume":"23","author":"B Atkinson","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"i1813","DOI":"10.1136\/bmj.i1813","article-title":"Couples at risk from exposure to Zika virus should consider delaying pregnancy, says CDC","volume":"352","author":"M McCarthy","year":"2016","journal-title":"BMJ"},{"issue":"02","key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12605","article-title":"Mechanisms and possible controls of the in utero Zika virus infection: Where is the Holy Grail?","volume":"77","author":"K Fuwa","year":"2017","journal-title":"Am J Reprod Immunol"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S1473-3099(16)30336-X","article-title":"Zika virus in semen and spermatozoa","volume":"16","author":"J M Mansuy","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"32","key":"ref71","doi-asserted-by":"crossref","first-page":"30316","DOI":"10.2807\/1560-7917.ES.2016.21.32.30316","article-title":"Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016","volume":"21","author":"L Barzon","year":"2016","journal-title":"Euro Surveill"},{"issue":"05","key":"ref73","doi-asserted-by":"crossref","first-page":"122","DOI":"10.15585\/mmwr.mm6505e2","article-title":"Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure \u2013 United States, 2016","volume":"65","author":"T Oduyebo","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"04","key":"ref74","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/14767058.2016.1174210","article-title":"The Zika virus and pregnancy: evidence, management, and prevention","volume":"30","author":"A Citil Dogan","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijid.2016.09.009","article-title":"Congenital and perinatal complications of chikungunya fever: a Latin American experience","volume":"51","author":"J R Torres","year":"2016","journal-title":"Int J Infect Dis"},{"issue":"02","key":"ref76","doi-asserted-by":"crossref","first-page":"30","DOI":"10.15585\/mmwr.mm6502e1","article-title":"Interim Guidelines for Pregnant Women During a Zika Virus Outbreak \u2013 United States, 2016","volume":"65","author":"E E Petersen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"03","key":"ref77","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5021\/ad.2011.23.3.265","article-title":"Dermatoses of pregnancy - clues to diagnosis, fetal risk and therapy","volume":"23","author":"C M Ambros-Rudolph","year":"2011","journal-title":"Ann Dermatol"},{"issue":"04","key":"ref78","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2105\/AJPH.2016.303113","article-title":"The Epidemic of Zika Virus-Related Microcephaly in Brazil: Detection, Control, Etiology, and Future Scenarios","volume":"106","author":"M G Teixeira","year":"2016","journal-title":"Am J Public Health"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/zika-virus-infection-in-pregnant-women-and-microcephaly\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1603450.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T18:59:51Z","timestamp":1721329191000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1603450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":65,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2017,6,2]]},"published-print":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1603450","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}