{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:57:13Z","timestamp":1774969033908,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n            Objectives\u2003The objective of this study was to describe survival, short-term, and long-term morbidities of neonates with birth weight\u2009&lt;\u2009500 g.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective cohort studies to calculate survival, short-term, and long-term morbidity rates of neonates born weighing\u2009&lt;\u2009500\u2009g from 1993 to 2012 and neurodevelopmental impairment rates at 4.5 years for births 1993 to 2008 in one center.<\/jats:p><jats:p>\n            Results\u2003Of 549 inborn neonates with birth weight\u2009&lt;\u2009500\u2009g, 4% survived. For live births and neonatal intensive care unit (NICU) admissions, 10 and 55% survived, respectively. Of 28 NICU (inborn and outborn) survivors (median birth weight 460\u2009g and gestation 25.9 weeks [range: 22.6\u201330.3 weeks]), 71% were inborn, 50% male, and 75% were small for gestational age. One in five neonates was a twin or multiple. Short-term morbidities noted were bronchopulmonary dysplasia (91%), culture proven sepsis (50%), retinopathy of prematurity (41%), and severe brain injury (22%); 27% had no long-term impairment, 23% one, 23% two, 18% three, and 9% four impairments in motor, cognitive, vision, and\/or hearing domains. At 4.5 years, 29% had visual impairment, 10% wore hearing aids, 50% had IQ\u2009&lt;\u200970, 18% cerebral palsy, and 68% had low motor scores.<\/jats:p><jats:p>\n            Conclusion\u2003Only 4% of births\u2009&lt;\u2009500\u2009g survived. All survivors had short-term morbidities; 27% neonates survived without long-term major impairments.<\/jats:p>","DOI":"10.1055\/s-0037-1603462","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T06:59:29Z","timestamp":1495522769000},"page":"1333-1339","source":"Crossref","is-referenced-by-count":9,"title":["Survival, Short-Term, and Long-Term Morbidities of Neonates with Birth Weight\u2009&lt;\u2009500 g"],"prefix":"10.1055","volume":"34","author":[{"given":"Rani","family":"Bashir","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne","family":"Thomas","sequence":"first","affiliation":[{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"MacKay","sequence":"first","affiliation":[{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Agnew","sequence":"first","affiliation":[{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Hubber-Richard","sequence":"first","affiliation":[{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Grunau","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"},{"name":"BC Children's Hospital Research Institute, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Synnes","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Neonatal Program, British Columbia's Women's Hospital, Vancouver, British Columbia, Canada"},{"name":"BC Children's Hospital Research Institute, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,5,22]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1603462.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T13:27:35Z","timestamp":1513690055000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1603462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,22]]},"references-count":0,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2017,10,19]]},"published-print":{"date-parts":[[2017,11]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1603462","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,22]]}}}