{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:14:56Z","timestamp":1778829296953,"version":"3.51.4"},"reference-count":16,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"06","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n            Purpose\u2003To evaluate maternal-fetal surveillance and follow-up of infants at risk for congenital syphilis (CS).<\/jats:p><jats:p>\n            Methods\u2003Retrospective cohort study in a Portuguese Tertiary Referral Hospital. The main inclusion criterion was a positive syphilis serology. The study included all pregnant women that delivered in our hospital between January 2004 and December 2013. The neonates were classified according to their probability of infection based on the Centers for Disease Control and Prevention guidelines.<\/jats:p><jats:p>\n            Results\u2003Among the 27 pregnancies at risk for CS, 48.2% (n\u2009=\u200913) of the women had a diagnosis during the 1st trimester, and the median gestational age at the end of the treatment was 28 weeks. Inadequate treatment was noted in 44.4% (n\u2009=\u200912) of the women. Adverse pregnancy outcomes were observed in 30.8% of the cases (n\u2009=\u20098), 5 of which had been adequately treated. We found 2 (7.7%) cases with \u201cproven or highly probable CS,\u201d 10 (38.5%) with \u201cpossible CS,\u201d 12 (46.1%) with \u201cless likely CS,\u201d and 2 (7.7%) with \u201cunlikely CS.\u201d Among the infants, the treatment was successful, except for 1 neurosyphilis case.<\/jats:p><jats:p>\n            Conclusion\u2003This study highlights many of the difficulties\/concerns encountered in the maternal-neonatal management of syphilis. We highlight the importance of assuring the early detection of the infection as a way of guaranteeing the timely treatment, as well as a good compliance to the treatment and follow-up through a more efficient pregnant women surveillance network.<\/jats:p>","DOI":"10.1055\/s-0037-1603646","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T22:42:03Z","timestamp":1497393723000},"page":"265-272","source":"Crossref","is-referenced-by-count":10,"title":["Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital"],"prefix":"10.61622","volume":"39","author":[{"given":"Magda","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Obstetric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edgia","family":"Basto","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lu\u00edsa","family":"Areia","sequence":"additional","affiliation":[{"name":"Obstetric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Franco","sequence":"additional","affiliation":[{"name":"Obstetric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eug\u00e9nia","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Obstetric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eul\u00e1lia","family":"Afonso","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Moura","sequence":"additional","affiliation":[{"name":"Obstetric Unit, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"},{"name":"Vice-Dean of Medicine Faculty, Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"e971","DOI":"10.1016\/j.ijid.2013.05.007","article-title":"Increasing trend of syphilis and infection resistance: a retrospective study","volume":"17","author":"J Gao","year":"2013","journal-title":"Int J Infect Dis"},{"key":"ref2","volume-title":"Annual epidemiological report 2014 - sexually transmitted infections, including HIV and blood-borne viruses","year":"2015"},{"key":"ref3","volume-title":"Annual epidemiological report 2014\u2013Congenital Syphilis","year":"2015"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2471\/BLT.12.107623","article-title":"Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis","volume":"91","author":"G B Gomez","year":"2013","journal-title":"Bull World Health Organ"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/jp.2016.158","article-title":"Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La R\u00e9union, 2008 to 2014","volume":"37","author":"M Le Chevalier de Pr\u00e9ville","year":"2017","journal-title":"J Perinatol"},{"key":"ref7","volume-title":"Norma DGS n\u00b0 037\/2011 de 30\/09\/2011 atualizada a 20\/12\/2013","year":"2013"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/QCO.0000000000000270","article-title":"Prevention and treatment of mother-to-child transmission of syphilis","volume":"29","author":"S Braccio","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(07)60074-9","article-title":"Syphilis in China: results of a national surveillance programme","volume":"369","author":"Z Q Chen","year":"2007","journal-title":"Lancet"},{"issue":"S 02","key":"ref11","first-page":"126","article-title":"Congenital syphilis","volume":"76","author":"L Finelli","year":"1998","journal-title":"Bull World Health Organ"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0301-2115(03)00238-0","article-title":"Universal antenatal screening for syphilis: is it still justified economically? 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