{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:16:06Z","timestamp":1760120166219},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Background\u2003Acute mesenteric ischemia following cardiovascular surgery is a rare but fatal complication. We established a new rat model for hemodynamic monitoring during mesenteric ischemia\/reperfusion (I\/R) and evaluated the impact of mesenteric I\/R on hemodynamics and remote organ injury.<\/jats:p>\n Methods\u2003Mesenteric I\/R was induced in male Wistar rats by superior mesenteric artery occlusion for 90 minutes, followed by 120 minutes of reperfusion. Before I\/R, ventilation and hemodynamic monitoring including mean arterial blood pressure (MAP) and cardiac output (CO) were established. During reperfusion Geloplasma (I\/R\u2009+\u2009Geloplasma, N\u2009=\u20096) and Ringer's solution (I\/R\u2009+\u2009Ringer, N\u2009=\u20096) were titrated according to CO and compared with I\/R without volume resuscitation (I\/R only, N\u2009=\u20096) and a sham group (sham, N\u2009=\u20096). Blood samples were regularly taken for serum marker measurements. After reperfusion organs were harvested for histology studies.<\/jats:p>\n Results\u2003After acute mesenteric I\/R, MAP and CO decreased (p\u2009<\u20090.01) while systemic and pulmonary vascular resistance increased (p\u2009<\u20090.01) continuously in the I\/R group. Volume substitution according to CO initially stabilized hemodynamic parameters, but CO declined independently in the late stage. Compared with the I\/R\u2009+\u2009Ringer group, the I\/R\u2009+\u2009Geloplasma group required less volume for resuscitation (p\u2009<\u20090.01), experienced less metabolic acidosis. I\/R groups had more organ injuries, more neutrophils sequestration, and higher creatine phosphokinase-MB levels than sham group.<\/jats:p>\n Conclusion\u2003A new model for CO monitoring after mesenteric I\/R injury demonstrated severe hypovolemic shock during reperfusion followed by remote myocardial and lung injury. Far less colloid volume is needed for hemodynamic stabilization after I\/R compared with crystalloid volume.<\/jats:p>","DOI":"10.1055\/s-0037-1603935","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T22:32:02Z","timestamp":1498602722000},"page":"099-108","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Acute Intestinal Ischemia and Reperfusion Injury on Hemodynamics and Remote Organs in a Rat Model"],"prefix":"10.1055","volume":"66","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital, Duisburg-Essen University, Essen, Germany"},{"name":"Department of Cardiac Surgery, Sun Yat-Sen University, Sun Yat-Sen Memorial Hospital, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Verhaegh","sequence":"first","affiliation":[{"name":"Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tsagakis","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital, Duisburg-Essen University, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Brencher","sequence":"first","affiliation":[{"name":"Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Zwanziger","sequence":"first","affiliation":[{"name":"Division of Laboratory Research, Department of Endocrinology and Metabolism, University Hospital Essen, University Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Jakob","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital, Duisburg-Essen University, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Groot","sequence":"first","affiliation":[{"name":"Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel-Sebastian","family":"Dohle","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital, Duisburg-Essen University, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,6,27]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1603935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T23:37:01Z","timestamp":1515541021000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1603935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2018,1,9]]},"published-print":{"date-parts":[[2018,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1603935","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]}}}