{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T08:31:08Z","timestamp":1662107468763},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n            Background\u2003We sought to determine the long-term results of stentless biological heart valve replacement in octogenarians to find out whether coronary artery disease or the coronary artery bypass grafting (CABG) procedure itself influences survival in these aged patients.<\/jats:p><jats:p>\n            Methods\u2003From 4,012 patients undergoing aortic valve replacement (AVR) with a stentless prosthesis (Freestyle, Medtronic) at a single center, 721 patients were older than 80 years. They had a mean age of 83\u2009\u00b1\u2009 2 (2,320 patient years), the male\/female ratio was 42:58, NYHA (New York Heart Association) class I and II was prevalent in 22.8%, preoperative atrial fibrillation (AF) in 20.6%, coronary artery disease in 56.1%, mitral valve disease in 12.5%, and aortic disease in 3.5%. Follow-up included a total of 11,546 patient years (mean follow-up time: 74\u2009\u00b1\u200953 months); follow-up mortality data were 96.3% complete.<\/jats:p><jats:p>\n            Results\u2003In these aged patients, 30-day mortality in the isolated AVR group (10.3%) was similar to that in the AVR\u2009+\u2009CABG group (13.4%). Although long-term survival (15 years) in the octogenarian population is low (9% in the AVR group and 6% in the AVR\u2009+\u2009CABG group), it was not different (p\u2009=\u20090.191) between patients with and without coronary artery disease. The stroke rate and the myocardial infarction rate, respectively, in the AVR\u2009+\u2009CABG group (0.43%\/100 patient years and 0.17%\/100 patient years) were only insignificantly higher than that in the isolated AVR group (each 0.01%\/100 patient years). The actuarial freedom from reoperation was 99% in both the groups.<\/jats:p><jats:p>\n            Conclusion\u2003Use of the Freestyle stentless valve prosthesis for AVR is feasible also in octogenarians. The existence of coronary artery disease leads to concomitant bypass surgery, but not a higher level of perioperative or long-term mortality.<\/jats:p>","DOI":"10.1055\/s-0037-1604048","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T22:47:22Z","timestamp":1499208442000},"page":"322-327","source":"Crossref","is-referenced-by-count":2,"title":["Stentless Bioprostheses for Aortic Valve Replacement in Octogenarians: The Influence of Coronary Artery Disease"],"prefix":"10.1055","volume":"66","author":[{"given":"Juergen","family":"Ennker","sequence":"first","affiliation":[{"name":"Herzzentrum, Helios Klinikum Siegburg, Siegburg, Germany"},{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t Witten-Herdecke, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Zadeh","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Medizin Statistik, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"},{"name":"Klinik f\u00fcr Herz-, Kinderherz- und Gef\u00e4\u00dfchirurgie, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Pons-Kuehnemann","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Medizin Statistik, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Niemann","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Herz-, Kinderherz- und Gef\u00e4\u00dfchirurgie, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Grieshaber","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Herz-, Kinderherz- und Gef\u00e4\u00dfchirurgie, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Ennker","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Plastische-, Hand- und Wiederherstellungschirurgie, Med. Hochschule Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Boening","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz-, Kinderherz- und Gef\u00e4\u00dfchirurgie, Justus-Liebig-Universit\u00e4t Gie\u00dfen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,7,4]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1604048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T22:31:22Z","timestamp":1528065082000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1604048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,4]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,6,3]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1604048","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,4]]}}}