{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:55:21Z","timestamp":1789808121894,"version":"4.0.1"},"reference-count":28,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"06","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n            Purpose\u2003To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis.<\/jats:p><jats:p>\n            Methods\u2003This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were genotyped by real-time polymerase chain reaction using the TaqMan system. The association of the polymorphisms with endometriosis was evaluated using the multivariate logistic regression.<\/jats:p><jats:p>\n            Results\u2003The endometriosis patients were significantly younger than the controls (36.0\u2009\u00b1\u20097.3 versus 38.0\u2009\u00b1\u20098.5 respectively, p\u2009=\u20090.023), and they had a lower body mass index (26.3\u2009\u00b1\u20094.8 versus 27.9\u2009\u00b1\u20095.7 respectively, p\u2009=\u20090.006), higher average duration of the menstrual flow (7.4\u2009\u00b1\u20094.9 versus 6.1\u2009\u00b1\u20094.4 days respectively, p\u2009=\u20090.03), and lower average time intervals between menstrual periods (25.2\u2009\u00b1\u20099.6 versus 27.5\u2009\u00b1\u200911.1 days respectively, p\u2009=\u20090.05). A higher prevalence of symptoms of dysmenorrhea, dyspareunia, chronic pelvic pain, infertility and intestinal or urinary changes was observed in the case group when compared with the control group. The interval between the onset of symptoms and the definitive diagnosis of endometriosis was 5.2\u2009\u00b1\u20096.9 years. When comparing both groups, significant differences were not observed in the allelic and genotypic frequencies of the polymorphisms PGR +331C\u2009&gt;\u2009T, CYP17A1 -34A\u2009&gt;\u2009G and CYP19A1 1531G\u2009&gt;\u2009A, even when considering the symptoms, classification and stage of the endometriosis. The combined genotype PGR +331TT\/CYP17A1 -34AA\/CYP19A11531AA is positively associated with endometriosis (odds ratio [OR]\u2009=\u20091.72; 95% confidence interval [95%CI]\u2009=\u20091.09\u20132.72).<\/jats:p><jats:p>\n            Conclusions\u2003The combined analysis of the polymorphisms PGR-CYP17A1-CYP19A1 suggests a gene-gene interaction in the susceptibility to endometriosis. These results may contribute to the identification of biomarkers for the diagnosis and\/or prognosis of the disease and of possible molecular targets for individualized treatments.<\/jats:p>","DOI":"10.1055\/s-0037-1604097","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T22:41:36Z","timestamp":1497480096000},"page":"273-281","source":"Crossref","is-referenced-by-count":13,"title":["Combined Effect of the PGR +331C\u2009&gt;\u2009T, CYP17A1 -34A\u2009&gt;\u2009G and CYP19A1 1531G\u2009&gt;\u2009A Polymorphisms on the Risk of Developing Endometriosis"],"prefix":"10.61622","volume":"39","author":[{"given":"J\u00e9ssica Vilarinho","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences, Pharmacy Unit, Centro Universit\u00e1rio Estadual da Zona Oeste, Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Post-graduation in Public Health and Natural Environment Program, Escola Nacional de Sa\u00fade P\u00fablica Sergio Arouca, Funda\u00e7\u00e3o Oswaldo Cruz (National School of Public Health, Oswaldo Cruz Foundation), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Escorsim","family":"Machado","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences, Pharmacy Unit, Centro Universit\u00e1rio Estadual da Zona Oeste, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Gynecology Institute, Universidade Federal do Rio de Janeiro, Hospital Moncorvo Filho, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Calixto da","family":"Silva","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences, Pharmacy Unit, Centro Universit\u00e1rio Estadual da Zona Oeste, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pl\u00ednio Tostes","family":"Berardo","sequence":"additional","affiliation":[{"name":"Gynecology Service, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila Alessandra","family":"Perini","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences, Pharmacy Unit, Centro Universit\u00e1rio Estadual da Zona Oeste, Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Post-graduation in Public Health and Natural Environment Program, Escola Nacional de Sa\u00fade P\u00fablica Sergio Arouca, Funda\u00e7\u00e3o Oswaldo Cruz (National School of Public Health, Oswaldo Cruz Foundation), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"242149","DOI":"10.1155\/2013\/242149","article-title":"Endometriosis: a disease that remains enigmatic","volume":"2013","author":"P Aci\u00e9n","year":"2013","journal-title":"ISRN Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1472-6874-14-117","article-title":"Role of vascular endothelial growth factor polymorphisms (-2578C\u2009>\u2009A, -460 T\u2009>\u2009C, -1154G\u2009>\u2009A, +405G\u2009>\u2009C and +936C\u2009>\u2009T) in endometriosis: a case-control study with Brazilians","volume":"14","author":"J A Perini","year":"2014","journal-title":"BMC Womens Health"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0036-1585408","article-title":"Beyond endometriosis genome-wide association study: from genomics to phenomics to the patient","volume":"34","author":"K T Zondervan","year":"2016","journal-title":"Semin Reprod Med"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1158\/1078-0432.CCR-07-5030","article-title":"Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms","volume":"14","author":"D W Bell","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.rbmo.2015.01.012","article-title":"Down-regulation of the CYP19A1 gene in cumulus cells of infertile women with endometriosis","volume":"30","author":"I D Barcelos","year":"2015","journal-title":"Reprod Biomed Online"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/1933719115585145","article-title":"Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants","volume":"22","author":"M A Bedaiwy","year":"2015","journal-title":"Reprod Sci"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humrep\/der346","article-title":"Deep infiltrating endometriosis is associated with markedly lower body mass index: a 476 case-control study","volume":"27","author":"M C Lafay Pillet","year":"2012","journal-title":"Hum Reprod"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-069X-13-19","article-title":"Polymorphisms in phase I and phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case-control study in Inuit women","volume":"13","author":"M Ghisari","year":"2014","journal-title":"Environ Health"},{"issue":"19","key":"ref9","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1073\/pnas.192172299","article-title":"A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk","volume":"99","author":"I De Vivo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/humrep\/17.4.897","article-title":"Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women","volume":"17","author":"N Kado","year":"2002","journal-title":"Hum Reprod"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF02729896","article-title":"Cytochrome P450c17alpha 5\u2032-untranslated region *T\/C polymorphism in endometriosis","volume":"83","author":"Y Y Hsieh","year":"2004","journal-title":"J Genet"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.fertnstert.2004.07.977","article-title":"Estrogen receptor alpha dinucleotide repeat and cytochrome P450c17alpha gene polymorphisms are associated with susceptibility to endometriosis","volume":"83","author":"Y Y Hsieh","year":"2005","journal-title":"Fertil Steril"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/humrep\/del033","article-title":"CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women","volume":"21","author":"S H Juo","year":"2006","journal-title":"Hum Reprod"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s10038-007-0174-x","article-title":"Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis","volume":"52","author":"S E Hur","year":"2007","journal-title":"J Hum Genet"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/humrep\/del325","article-title":"Progesterone receptor polymorphism +331G\/A is associated with a decreased risk of deep infiltrating endometriosis","volume":"22","author":"K J van Kaam","year":"2007","journal-title":"Hum Reprod"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.fertnstert.2008.07.1786","article-title":"CYP17 and CYP19 gene polymorphisms in women affected with endometriosis","volume":"92","author":"M T Vietri","year":"2009","journal-title":"Fertil Steril"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.rbmo.2009.11.007","article-title":"CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis","volume":"20","author":"G Bozdag","year":"2010","journal-title":"Reprod Biomed Online"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/09513590.2010.495434","article-title":"Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis","volume":"27","author":"M Lamp","year":"2011","journal-title":"Gynecol Endocrinol"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.fertnstert.2011.09.004","article-title":"Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes","volume":"96","author":"B Trabert","year":"2011","journal-title":"Fertil Steril"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1038\/emm.2014.31","article-title":"CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women","volume":"46","author":"L Wang","year":"2014","journal-title":"Exp Mol Med"},{"issue":"06","key":"ref21","first-page":"692","article-title":"[Association of the CYP19 gene polymorphism with genetic susceptibility to endometriosis]","volume":"27","author":"X Yang","year":"2010","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil Steril"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(97)00191-X","article-title":"Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities","volume":"68","author":"M Nisolle","year":"1997","journal-title":"Fertil Steril"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/humrep\/der462","article-title":"Ovarian endometrioma: severe pelvic pain is associated with deeply infiltrating endometriosis","volume":"27","author":"C Chapron","year":"2012","journal-title":"Hum Reprod"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"436589","DOI":"10.1155\/2013\/436589","article-title":"The importance and perspective of magnetic resonance imaging in the evaluation of endometriosis","volume":"2013","author":"A Bianek-Bodzak","year":"2013","journal-title":"BioMed Res Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jmig.2015.08.148","article-title":"Correlation between magnetic resonance imaging results and findings at surgery for cases of severe endometriosis","volume":"22","author":"K Ma","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00404-015-3892-x","article-title":"Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis","volume":"293","author":"M B Barcellos","year":"2016","journal-title":"Arch Gynecol Obstet"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.fertnstert.2016.10.024","article-title":"Magnetic resonance imaging correlation to intraoperative findings of deeply infiltrative endometriosis","volume":"107","author":"T E Ito","year":"2017","journal-title":"Fertil Steril"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/combined-effect-of-the-pgr-331c-t-cyp17a1-34a-g-and-cyp19a1-1531g-a-polymorphisms-on-the-risk-of-developing-endometriosis\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1604097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T19:08:06Z","timestamp":1721329686000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1604097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":28,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2017,7,3]]},"published-print":{"date-parts":[[2017,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1604097","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}