{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:19:22Z","timestamp":1773278362068,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n Introduction\u2003Patients after pull-through operation for Hirschsprung's disease (HD) are at high risk of defecation disorders. This study aimed at investigating their long-term outcomes and quality of life (QoL) in comparison with controls.<\/jats:p>\n Patients and Methods\u2003Patients older than 5 years operated on for HD were interviewed to complete detailed questionnaires on bowel function. Patients without neurologic impairment were enrolled in a QoL survey to compare with controls matched for sex and age and selected randomly from the general population using sampling set in a ratio of four controls to one case of HD.<\/jats:p>\n Results\u2003In total, 53 operated patients were enrolled. Mean age of the patients was 16\u2009\u00b1\u20098 years, with 68% boys. Rectosigmoid aganglionosis was the most seen form of HD in 38 (72%) cases. Open Soave was performed in 40 (75.5%) cases, and minimally invasive surgery Soave (MIS Soave) in 13 (24.5%) cases. At investigation, prevalence of fecal incontinence and constipation were 22.6 and 13.2%, respectively. Regarding QoL survey, 45 patients and 180 controls were enrolled, excluding 8 patients with neurologic impairment. Thirty-seven (82.2%) patients were classified as having a good QoL (score\u2009\u2265\u20099 points); whereas six had a fair QoL (5\u20138 points) and two had a poor QoL (< 5 points). QoL score in the cases and the controls were 10.2\u2009\u00b1\u20092.5 and 11.9\u2009\u00b1\u20090.4 points, respectively. Long aganglionosis form of HD was significantly associated with a low QoL (score\u2009<\u20098 points), adjusted odds ratio\u2009=\u20099, 95% confidence interval [1.3; 64.1] (p\u2009<\u20090.05). In subscales analyses, the prevalence of each dimension including fecal continence, school absenteeism, unhappiness or anxiety, food restriction, and peer rejection was significantly higher in operated patients than in controls (p\u2009<0.001).<\/jats:p>\n Conclusion\u2003Although the QoL of patients operated on for HD in general was with good outcomes, fecal incontinence and constipation still are problematic issues and challenges in a high percentage of patients. Therefore, a long-term and multidisciplinary follow-up is essentially required for these patients.<\/jats:p>","DOI":"10.1055\/s-0037-1604115","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T22:36:16Z","timestamp":1500935776000},"page":"445-454","source":"Crossref","is-referenced-by-count":19,"title":["Long-Term Outcomes and Quality of Life in Patients after Soave Pull-Through Operation for Hirschsprung's Disease: An Observational Retrospective Study"],"prefix":"10.1055","volume":"28","author":[{"given":"Tania","family":"Mahler","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, H\u00f4pital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgique \u2014 Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Dassonville","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgique \u2014 Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinh","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, City Children's Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Robert","sequence":"first","affiliation":[{"name":"Facult\u00e9 de sant\u00e9 publique, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Goyens","sequence":"first","affiliation":[{"name":"Laboratory of Pediatrics, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Steyaert","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgique \u2014 Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, City Children's Hospital, Ho Chi Minh City, Vietnam"},{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgique \u2014 Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,7,24]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1604115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T22:59:26Z","timestamp":1538780366000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1604115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,10,5]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1604115","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]}}}