{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T16:34:22Z","timestamp":1688056462919},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n            Introduction\u2003Several urethroplasties have been employed in the surgical treatment of hypospadias. Neourethral strictures are among the most common postoperative complications that often require reoperation.<\/jats:p><jats:p>\n            Materials and Methods\u2003We created a hypospadias model in New Zealand white male rabbits through a hypospadias-like defect and acute repair. A total of 24 animals were randomly allocated into three groups: tubularized incised-plate urethroplasty (TIPU) group (8), perimeatal-based flap urethroplasty (Mathieu) group (8), onlay island flap urethroplasty (onlay) group (8), and corresponding surgical procedures were immediately performed to reconstruct neourethra. The rabbits were killed postoperatively at 5 days, 2 weeks, 6 weeks, and 3 months, respectively. The penile tissue was harvested for histological and biochemical investigations to evaluate the expressions of transforming growth factor \u03b21 (TGF-\u03b21) and \u03b1-smooth muscle actin (\u03b1-SMactin) in all groups.<\/jats:p><jats:p>\n            Results\u2003All rabbits were operated on uneventfully. The amount of collagen content was increased in the Mathieu and onlay groups than in the TIPU group (p\u2009&lt;\u20090.05). Biochemical analysis showed that the expression of TGF-\u03b21 in the TIPU group was decreased compared with the two other groups at 2 or 6 weeks postoperatively (p\u2009&lt;\u20090.01). The expression pattern regarding \u03b1-SMactin was similar at 6 weeks or 3 months postoperatively (p\u2009&lt;\u20090.01).<\/jats:p><jats:p>\n            Conclusion\u2003The neourethra repaired by TIPU was practically resumed to normal anatomy and scarring was less apparent than the two other groups. Therefore, TIPU is considered as a relatively rational approach for hypospadias repair. The activity of fibroblasts has been increased in the long term, which may be the pathogenesis of neourethral stricture following hypospadias repair.<\/jats:p>","DOI":"10.1055\/s-0037-1605347","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T22:52:50Z","timestamp":1503615170000},"page":"420-425","source":"Crossref","is-referenced-by-count":5,"title":["Histological and Biochemical Evaluation of Urethral Scar following Three Different Hypospadias Repairs: An Experimental Study in Rabbits"],"prefix":"10.1055","volume":"28","author":[{"given":"Xiao-Hui","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Lan","family":"Long","sequence":"first","affiliation":[{"name":"Ministry of Education, Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China"},{"name":"Chongqing Key Laboratory of Child Urogenital Development and Tissue Engineering, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Wei","family":"He","sequence":"first","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Hui","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,8,24]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1605347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T22:59:23Z","timestamp":1538780363000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1605347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,24]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,10,5]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1605347","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,24]]}}}