{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:12:07Z","timestamp":1788383527805,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2018,12]]},"abstract":"\n Purpose\u2003The relationship between pulmonary hypoplasia and pulmonary arterial hypertension (PHTN) in patients with congenital diaphragmatic hernia (CDH) remains ill-defined. We hypothesized that prenatal estimates of lung size would directly correlate with PHTN severity.<\/jats:p>\n Methods\u2003Infants with isolated CDH (born 2004\u20132015) at a single institution were included. Estimates of lung size included observed-to-expected LHR (o:eLHR) and %-predicted lung volumes (PPLV\u2009=\u2009observed\/predicted volumes). The primary outcome was severity of PHTN (grade 0\u20133) on echocardiography performed between day of life 3 and 30.<\/jats:p>\n Results\u2003Among 62 patients included, there was 32% mortality and 65% ECMO utilization. PPLV (odds ratio [OR]\u2009=\u20090.94 per 1 grade in PHTN severity, 95% confidence interval [CI]\u2009=\u20090.89\u20130.98, p\u2009<\u20090.01) and o:eLHR (OR\u2009=\u20090.97, 95% CI\u2009=\u20090.94\u20130.99, p\u2009<\u20090.01) were significantly associated with PHTN grade. Among patients on ECMO, PPLV (OR\u2009=\u20090.92, 95% CI\u2009=\u20090.84\u20130.99, p\u2009=\u20090.03) and o:eLHR (OR\u2009=\u20090.95, 95% CI\u2009=\u20090.92\u20130.99, p\u2009=\u20090.01) were more strongly associated with PHTN grade. PPLV and o:eLHR were significantly associated with the use of inhaled nitric oxide (iNO) (OR\u2009=\u20090.90, 95% CI\u2009=\u20090.83\u20130.98, p\u2009=\u20090.01 and OR\u2009=\u20090.94, 95% CI\u2009=\u20090.91\u20130.98, p\u2009<\u20090.01, respectively) and epoprostenol (OR\u2009=\u20090.91, 95% CI\u2009=\u20090.84\u20130.99, p\u2009=\u20090.02 and OR\u2009=\u20090.93, 95% CI\u2009=\u20090.89\u20130.98, p\u2009<\u20090.01, respectively).<\/jats:p>\n Conclusion\u2003Among infants with isolated CDH, PPLV, and o:eLHR were significantly associated with PHTN severity, especially among patients requiring ECMO. Prenatal lung size may help predict postnatal PHTN and associated therapies.<\/jats:p>","DOI":"10.1055\/s-0037-1607291","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T18:39:29Z","timestamp":1508179169000},"page":"508-514","source":"Crossref","is-referenced-by-count":14,"title":["Pulmonary Hypertension in Patients with Congenital Diaphragmatic Hernia: Does Lung Size Matter?"],"prefix":"10.1055","volume":"28","author":[{"given":"Arin","family":"Madenci","sequence":"first","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gajarski","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Nationwide Children's Hospital, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Marchetti","sequence":"first","affiliation":[{"name":"Department of Education, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Education, University of Michigan Medical School, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Coughlin","sequence":"first","affiliation":[{"name":"Department of Surgery, Henry Ford Health System, Detroit, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Kreutzmann","sequence":"first","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Treadwell","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ladino-Torres","sequence":"first","affiliation":[{"name":"Section of Pediatric Radiology, Department of Radiology, University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mychaliska","sequence":"first","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,10,16]]},"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1607291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T18:31:31Z","timestamp":1541874691000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1607291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,16]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2018,11,10]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1607291","relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,16]]}}}