{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:06:17Z","timestamp":1778857577395,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This observational study aimed to investigate the efficacy and safety of non\u2013vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with malignancy. A total of 76 patients (mean age: 73.2\u2009\u00b1\u20098.9; 28 females) with AF and malignancy treated with NOAC were included in the analysis. The mean CHA2DS2-VASc and HAS-BLED scores were 3.2\u2009\u00b1\u20091.2 and 2.2\u2009\u00b1\u20090.9, respectively. The study population was taking dabigatran 150\u2009mg (25%) twice daily (BID), apixaban 5\u2009mg BID (25%), dabigatran 110\u2009mg BID (24%), rivaroxaban 20\u2009mg (18%) once a day (OD), rivaroxaban 15\u2009mg OD (5%), or apixaban 2.5\u2009mg OD (3%). NOAC therapy began, on average, 248\u2009\u00b1\u2009238 days before malignancy diagnosis for an average duration of 1,000\u2009\u00b1\u2009289 days. Stroke, transient ischemic attack, major and minor bleeding events, other adverse effects, and major cardiovascular complications during the follow-up period were collected. In our study population, no patients experienced thromboembolic events during therapy with any NOAC. We recorded a low global incidence of major bleeding (3.9%) with a mean annual incidence of 1.4%. No hemorrhagic stroke or subarachnoid hemorrhage was observed. Only nine patients (11.8%) experienced minor bleeding. According to our data, anticoagulation therapy with NOACs seems to be an effective and safe treatment strategy for nonvalvular AF patients with malignancy.<\/jats:p>","DOI":"10.1055\/s-0037-1607436","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T18:47:03Z","timestamp":1512758823000},"page":"370-376","source":"Crossref","is-referenced-by-count":37,"title":["Use of Non\u2013Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients with Malignancy: Clinical Practice Experience in a Single Institution and Literature Review"],"prefix":"10.1055","volume":"44","author":[{"given":"Anna","family":"Rago","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Papa","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Meo","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Attena","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fatebenefratelli Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Golino","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"D'Onofrio","sequence":"first","affiliation":[{"name":"Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Nigro","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,8]]},"container-title":["Seminars in Thrombosis and Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1607436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T18:36:20Z","timestamp":1527878180000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1607436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,8]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1607436","relation":{},"ISSN":["0094-6176","1098-9064"],"issn-type":[{"value":"0094-6176","type":"print"},{"value":"1098-9064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,8]]}}}