{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:40:54Z","timestamp":1757702454944},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"\n Objective\u2003The objective of this study was to evaluate the impact of pregnancy history and 17-hydroxyprogesterone caproate (17-OHPC) treatment on cervical fluid cytokines and matrix metalloproteinases (MMPs).<\/jats:p>\n Study Design\u2003Cervical fluid was obtained between 160\/7 and 246\/7 weeks from women with only prior term births (controls, n\u2009=\u200926), women with one or more prior spontaneous preterm births (SPTBs) choosing to receive 17-OHPC (17-OHPC, n\u2009=\u200924), or to not receive 17-OHPC (refusers, n\u2009=\u200912). Cervical fluid collections were repeated 2, 4, and 8 weeks after the first sample and concentrations of MMPs and cytokines were measured by multiplex immune assay.<\/jats:p>\n Results\u2003Among women whose earliest prior delivery occurred between 16 and 23 weeks, cervical fluid concentration of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-\u03b1 at baseline were significantly elevated when compared with cervical cytokines of women whose earliest delivery occurred between 32 and 36 weeks (relative risk ratio was 3.37 for IL-6 [95% confidence interval, CI, 1.08\u201310.53, p\u2009<\u20090.05], 2.81 for IL-10 [95% CI, 1.39\u20135.70, p\u2009<\u20090.05], and 6.34 for TNF-\u03b1 [95% CI, 2.19\u201318.68, p\u2009<\u20090.001]). Treatment with 17-OHPC had no significant impact on these cytokines.<\/jats:p>\n Conclusion\u2003The cervical fluid of women with a history of an early prior SPTB is characterized by inflammation that is unaffected by 17-OHPC.<\/jats:p>","DOI":"10.1055\/s-0037-1608631","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T18:43:11Z","timestamp":1510771391000},"page":"470-480","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Pregnancy History and 17-Hydroxyprogesterone Caproate on Cervical Cytokines and Matrix Metalloproteinases"],"prefix":"10.1055","volume":"35","author":[{"given":"Gary","family":"Hankins","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Hebert","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Washington, Seattle, Washington"},{"name":"Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyagriv","family":"Simhan","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Haneline","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Indiana University, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Famy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Yorio","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Ren","sequence":"first","affiliation":[{"name":"Obstetric and Pediatric Pharmacology and Therapeutics Branch, Eunice Shriver National Institute of Child Health and Human Development, National Institutes of Health, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"D'Alton","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Venkataramanan","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,15]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1608631.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T18:36:10Z","timestamp":1522348570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1608631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,3,29]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1608631","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}