{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:50:38Z","timestamp":1778161838956,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n            Introduction\u2003Necrotizing enterocolitis (NEC) is one of the major health problems of newborn period. To date, a large amount of chemicals have been tested for NEC and some showed limited beneficial effects. The research for better results still continues. This study aims to investigate the effects of quercetin (QE) on NEC treatment in rats.<\/jats:p><jats:p>\n            Methods\u2003Newborn rats were divided into control, NEC, and NEC\u2009+\u2009QE groups. In NEC and NEC\u2009+\u2009QE groups, experimental NEC was induced. NEC\u2009+\u2009QE group animals were also given QE. Weight changes of the animals were recorded, and serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), and glutathione (GSH) levels were measured. Histologic evaluation of the distal ileum and the terminal deoxynucleotidyl transferase dUTP nick end labeling staining were performed.<\/jats:p><jats:p>\n            Results\u2003A significant increase in the TAS levels was observed in NEC\u2009+\u2009QE group. Only NEC group exhibited significantly higher TOS and MDA levels and lower GSH levels. Rats in the NEC\u2009+\u2009QE group had better histopathology and less apoptosis than NEC group.<\/jats:p><jats:p>\n            Conclusion\u2003QE is effective in enhancing antioxidant defense mechanism, limiting oxidative stress, reducing intestinal damage, and preventing NEC development.<\/jats:p>","DOI":"10.1055\/s-0037-1608660","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T23:48:15Z","timestamp":1510616895000},"page":"434-440","source":"Crossref","is-referenced-by-count":17,"title":["Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model"],"prefix":"10.1055","volume":"35","author":[{"given":"Cansu","family":"Ozcan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Hismiogullari","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Sunay","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teoman","family":"Ozcan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Berksoy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dr Beh\u00e7et Uz Pediatric Hospital, \u0130zmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Aksoz","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sel\u00e7uk","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,13]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1608660.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T22:36:06Z","timestamp":1522362966000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1608660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,3,29]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1608660","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]}}}