{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:19:34Z","timestamp":1761920374364},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>\n            Objective\u2003To identify the demographics, clinical characteristics, disease course, treatment patterns, and disability levels of multiple sclerosis (MS) patients with onset under the age of 10 years (early onset multiple sclerosis, EOMS).<\/jats:p><jats:p>\n            Methods\u2003EOMS patients were reviewed retrospectively in detailed records from 27 child neurology centers. Patients with preschool (\u22647 years) and school age (&gt;7 years) onset were compared.<\/jats:p><jats:p>\n            Results\u2003There were 30 children (16 girls, 14 boys) who have disease onset between 4 and 10 (mean8.1\u2009\u00b1\u20091.8) years. MS was relapsing\u2013remitting in 29 (96.7%) and primary progressive in one (3.3%) of the patients. In patients with onset \u22647 years, motor symptoms (54.5%) and encephalopathy (45.5%) predominated, while in those with onset &gt;7 years brainstem (42.1%), sensory (26.3%), and optic nerve (26.3%) involvement were the most frequent presentations.<\/jats:p><jats:p>\n            Conclusions\u2003MS starting \u22647 years differs from the 7\u201310\u2013year-old group by the higher rate of motor symptoms and more attacks in the first year: the latter suggests a more inflammatory character for EOMS.<\/jats:p>","DOI":"10.1055\/s-0037-1608776","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T23:31:49Z","timestamp":1511911909000},"page":"051-058","source":"Crossref","is-referenced-by-count":5,"title":["Multiple Sclerosis with Onset Younger Than 10 Years in Turkey"],"prefix":"10.1055","volume":"49","author":[{"given":"\u00dcnsal","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Dr. Beh\u00e7et Uz Children's Hospital, \u0130zmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahad\u0131r","family":"Konu\u015fkan","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u0131v\u0131lc\u0131m","family":"G\u00fcc\u00fcyener","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercan","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Anlar","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Hacettepe University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Turkish Pediatric Multiple Sclerosis Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,28]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1608776.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T23:33:07Z","timestamp":1516145587000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1608776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2018,1,16]]},"published-print":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1608776","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"type":"print","value":"0174-304X"},{"type":"electronic","value":"1439-1899"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}