{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:18:25Z","timestamp":1771676305991,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n            Objective\u2003To compare the risks of adverse maternal and neonatal outcomes associated with spontaneous (SPTB) versus indicated preterm births (IPTB).<\/jats:p><jats:p>\n            Methods\u2003A secondary analysis of a multicenter trial of vitamin C and E supplementation in healthy low-risk nulliparous women. Outcomes were compared between women with SPTB (due to spontaneous membrane rupture or labor) and those with IPTB (due to medical or obstetric complications). A primary maternal composite outcome included: death, pulmonary edema, blood transfusion, adult respiratory distress syndrome (RDS), cerebrovascular accident, acute tubular necrosis, disseminated intravascular coagulopathy, or liver rupture. A neonatal composite outcome included: neonatal death, RDS, grades III or IV intraventricular hemorrhage (IVH), sepsis, necrotizing enterocolitis (NEC), or retinopathy of prematurity.<\/jats:p><jats:p>\n            Results\u2003Of 9,867 women, 10.4% (N\u2009=\u20091,038) were PTBs; 32.7% (n\u2009=\u2009340) IPTBs and 67.3% (n\u2009=\u2009698) SPTBs. Compared with SPTB, the composite maternal outcome was more frequent in IPTB\u20144.4% versus 0.9% (adjusted odds ratio [aOR], 4.0; 95% confidence interval [CI], 1.4\u201311.8), as were blood transfusion and prolonged hospital stay (3.2 and 3.7 times, respectively). The frequency of composite neonatal outcome was higher in IPTBs (aOR, 1.8; 95% CI, 1.1\u20133.0), as were RDS (1.7 times), small for gestational age (SGA)\u2009&lt;\u20095th percentile (7.9 times), and neonatal intensive care unit (NICU) admission (1.8 times).<\/jats:p><jats:p>\n            Conclusion\u2003Adverse maternal and neonatal outcomes were significantly more likely with IPTB than with SPTB.<\/jats:p>","DOI":"10.1055\/s-0037-1608787","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T23:42:52Z","timestamp":1512085372000},"page":"624-631","source":"Crossref","is-referenced-by-count":8,"title":["Adverse Maternal and Neonatal Outcomes in Indicated Compared with Spontaneous Preterm Birth in Healthy Nulliparas: A Secondary Analysis of a Randomized Trial"],"prefix":"10.1055","volume":"35","author":[{"given":"Lindsay","family":"Doherty","sequence":"first","affiliation":[{"name":"The Biostatistics Center, The George Washington University, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Myatt","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Leveno","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Varner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Wapner","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"John","family":"Thorp","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Mercer","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Peaceman","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Ramin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Iams","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Sciscione","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Harper","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Tolosa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Saade","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Sorokin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,30]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1608787.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T22:31:22Z","timestamp":1526077882000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1608787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2018,5,11]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1608787","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}