{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:34:12Z","timestamp":1789932852556,"version":"4.0.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Angiol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n            Background\u2003There is no consensus regarding the role of red blood cell (RBC) aggregation in the pathogenesis of leg ulcers (LUs) in sickle cell disease (SCD).<\/jats:p><jats:p>\n            Objectives\u2003We sought to evaluate whether the cross-sectional determination of RBC aggregation and hematological indices were associated with the presence of LU in homozygous SCD.<\/jats:p><jats:p>\n            Methods\u2003Twenty-seven patients with LU and 23 with no history of ulceration were recruited into the study. A laser-assisted rotational red cell analyzer (LoRRca) was used in the determination of the aggregation index (AI), aggregation half-time (t\n            1\/2), and the RBC aggregate strength (AMP). Hematological indices were determined using a CELL-DYN Ruby analyzer. Whole blood viscosity (WBV) and plasma viscosity (PV) were measured using a Vilastic bioprofiler. The data were presented as means\u2009\u00b1\u2009standard deviation or median, interquartile range. Two-sample t-test was used to test for associations between the AIs, WBV, and PV in patients with and without LU. Statistical significance was taken as p\u2009&lt;\u20090.05. All analyses were conducted using Stata\/SE v. 12.1 (StataCorp, College Station, TX).<\/jats:p><jats:p>\n            Results\u2003The AI was comparable in the group with and without ulcers (68.6, 16.7 versus 67.7, 16.9; p\u2009=\u20090.74); t\n            1\/2 (1.7, 1.3 versus 1.8, 1.3; p\u2009=\u20090.71); AMP (18.8, 14.5 versus 19.1, 13.3; p\u2009=\u20090.84), WBV (3.8, 1.2 versus 3.8, 0.7; p\u2009=\u20090.77); and the PV (1.3, 0.08 versus 1.4, 0.1; p\u2009=\u20090.31) and were also not statistically different between the groups of participants.<\/jats:p><jats:p>\n            Conclusion\u2003RBC aggregation and aggregate strength are not associated with leg ulceration in SCD.<\/jats:p>","DOI":"10.1055\/s-0037-1608901","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T23:44:41Z","timestamp":1518219881000},"page":"035-038","source":"Crossref","is-referenced-by-count":6,"title":["Erythrocyte Aggregation and Blood Viscosity is Similar in Homozygous Sickle Cell Disease Patients with and without Leg Ulcers"],"prefix":"10.1055","volume":"27","author":[{"given":"Walworth","family":"Duncan","sequence":"first","affiliation":[{"name":"Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Jamaica, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pepple","sequence":"first","affiliation":[{"name":"Physiology Section, Department of Basic Medical Sciences, University of the West Indies, Mona, Jamaica, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Bowers","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Basic Medical Sciences, University of the West Indies, Mona, Jamaica, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,2,9]]},"container-title":["International Journal of Angiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1608901.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T23:32:56Z","timestamp":1519428776000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1608901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2018,2,23]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1608901","relation":{},"ISSN":["1061-1711","1615-5939"],"issn-type":[{"value":"1061-1711","type":"print"},{"value":"1615-5939","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}