{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:48:20Z","timestamp":1760784500002,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"20","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["MH096463"],"award-info":[{"award-number":["MH096463"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["NS076517"],"award-info":[{"award-number":["NS076517"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synthesis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>An improved synthesis of the anxiolytic, anticonvulsant, and antinociceptive compounds: Hz-166, and its bioisosteres 1,2,4-oxadiazole (MP-III-080) and 1,3-oxazole (KRM-II-81) were synthesized in higher yields and with more facile purification methods (crystallization, etc.) in multigram quantities without column chromatography. In the synthesis of KRM-II-81, an alternative procedure was employed using the selective reducing reagent, potassium diisobutyl-tert-butoxyaluminum hydride (PDBBA), to prepare the desired C(3)-aldehyde in the absence of N(5)\u2013C(6) imine reduction in good yield on a 20 gram scale.<\/jats:p>","DOI":"10.1055\/s-0037-1610211","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T19:31:21Z","timestamp":1532460681000},"page":"4124-4132","source":"Crossref","is-referenced-by-count":12,"title":["Improved Synthesis of Anxiolytic, Anticonvulsant, and Antinociceptive \u03b12\/\u03b13-GABA(A)-ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, and Neuropathic Pain"],"prefix":"10.1055","volume":"50","author":[{"given":"James","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-0348","authenticated-orcid":false,"given":"Guanguan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalit","family":"Golani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajwana","family":"Jahan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farjana","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,24]]},"container-title":["Synthesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1610211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T18:35:53Z","timestamp":1538505353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1610211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,24]]},"references-count":0,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2018,10,2]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1610211","relation":{},"ISSN":["0039-7881","1437-210X"],"issn-type":[{"type":"print","value":"0039-7881"},{"type":"electronic","value":"1437-210X"}],"subject":[],"published":{"date-parts":[[2018,7,24]]}}}