{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:58:32Z","timestamp":1773701912565,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is an observational study to investigate the efficacy and safety of nonvitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with bioprosthetic valves or prior surgical valve repair in clinical practice. A total of 122 patients (mean age: 74.1\u2009\u00b1\u200913.2; 54 females) with bioprosthetic heart valve or surgical valve repair and AF treated with NOACs were included in the analysis. The mean CHA2DS2-VASc (Congestive heart failure, Hypertension, Age &gt;75 years, Diabetes mellitus, prior Stroke or transient ischemic attack, Vascular disease) and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR [international normalized ratio], Elderly, Drugs or alcohol) score values were 3.6\u2009\u00b1\u20091.2 and 2.6\u2009\u00b1\u20091.4, respectively. Of the total study population, 28.6% was taking apixaban 5\u2009mg twice daily (BID), 24.5% apixaban 2.5\u2009mg BID, 18% dabigatran 150\u2009mg BID, 13% dabigatran 110\u2009mg BID, 9.8% rivaroxaban 20\u2009mg daily (QD), and 5.7% rivaroxaban 15\u2009mg QD. Also, 92% of the study population previously had warfarin replaced with NOACs due to lack compliance and labile INR control (time in therapeutic range\u2009&lt;\u200960%). NOAC therapy for AF was started on average 934\u2009\u00b1\u2009567 days after bioprosthetic heart valve implantation or surgical repair for an average duration of 835\u2009\u00b1\u2009203 days. The study population included 24 (19.6%) patients with bioprosthetic mitral valve, 52 (43%) patients with bioprosthetic aortic valve, 41 (33.6%) patients with previous surgical mitral repair, 5 (4%) patients with previous surgical aortic repair, and concomitant use of NOACs. All patients were evaluated for thromboembolic events (ischemic stroke, transient ischemic attack, systemic embolism) as well as major bleeding events during the follow-up period. In our study population, we recorded a low mean annual incidence of thromboembolism (0.8%) and major bleeding (1.3%). According to our data, anticoagulation therapy with NOACs seems to be an effective and a safe treatment strategy for nonvalvular AF patients with bioprosthetic valves or prior surgical valve repair.<\/jats:p>","DOI":"10.1055\/s-0037-1615261","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T18:44:12Z","timestamp":1515177852000},"page":"364-369","source":"Crossref","is-referenced-by-count":39,"title":["Nonvitamin K Antagonist Oral Anticoagulants Use in Patients with Atrial Fibrillation and Bioprosthetic Heart Valves\/Prior Surgical Valve Repair: A Multicenter Clinical Practice Experience"],"prefix":"10.1055","volume":"44","author":[{"given":"Emilio","family":"Attena","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fatebenefratelli Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Mazzone","sequence":"first","affiliation":[{"name":"Cardiovascular Centre, Health Authority 1, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Cardiology, San Giovanni di Dio e Ruggi d'Aragona Hospital, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Parisi","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Bancone","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rago","sequence":"first","affiliation":[{"name":"Chair of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Nigro","sequence":"first","affiliation":[{"name":"Chair of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Sangiuolo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fatebenefratelli Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"D' Onofrio","sequence":"first","affiliation":[{"name":"Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Russo","sequence":"additional","affiliation":[{"name":"Chair of Cardiology, University of Campania \u201cLuigi Vanvitelli,\u201d Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,5]]},"container-title":["Seminars in Thrombosis and Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1615261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T18:36:21Z","timestamp":1527878181000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1615261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,5]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1615261","relation":{},"ISSN":["0094-6176","1098-9064"],"issn-type":[{"value":"0094-6176","type":"print"},{"value":"1098-9064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,5]]}}}