{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:20:38Z","timestamp":1761844838691},"reference-count":17,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"01","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. But what to do when identifying an even more infrequent sarcoma in a premenopausal woman? In this study, we describe the case of a 53-year-old woman presenting with metrorrhagia for two months, who was evaluated after an intense episode. A necrotic and ulcerative vaginal swelling was documented and then submitted to biopsy, which revealed a vaginal sarcoma. The patient was referred to radiation therapy with 50\u2009Gy (aiming to control the symptoms and to cause tumor reduction for posterior pelvic exenteration with intraoperative radiotherapy) and developed an extra-pelvic metastization at the end of the treatment, which caused a fast negative outcome. Despite the initial poor prognosis, a chemo-irradiation or primary surgery regimen might have achieved (although with greater side effects) a better survival. This case-report entails a discussion about the strategies to manage vaginal sarcoma in advanced stage and in premenopausal women.<\/jats:p>","DOI":"10.1055\/s-0037-1615293","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T23:36:48Z","timestamp":1516145808000},"page":"047-052","source":"Crossref","is-referenced-by-count":3,"title":["When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma"],"prefix":"10.61622","volume":"40","author":[{"given":"Pedro","family":"Marcos-Figueiredo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia\/Obstetr\u00edcia, Hospital Senhora da Oliveira Guimar\u00e3es, Guimar\u00e3es, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana de Sousa da Costa","family":"Moreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radiologia, Instituto Portugu\u00eas Oncologia do Porto Francisco Gentil, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Gon\u00e7alves","family":"Morim","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia\/Obstetr\u00edcia, Centro Hospitalar da P\u00f3voa de Varzim\/Vila do Conde, P\u00f3voa de Varzim, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia Leite","family":"Pereira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Ginecologia\/Obstetr\u00edcia, Centro Hospitalar da P\u00f3voa de Varzim\/Vila do Conde, P\u00f3voa de Varzim, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lurdes Silva","family":"Salgado","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radiologia, Instituto Portugu\u00eas Oncologia do Porto Francisco Gentil, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"R L Siegel","year":"2015","journal-title":"CA Cancer J Clin"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/0002-9378(66)90519-9","article-title":"Primary carcinoma of the vagina","volume":"96","author":"L J Dunn","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"ref3","volume-title":"Primary carcinoma of the vagina","author":"R C Livingston","year":"1950"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0002-9378(70)90581-8","article-title":"Embryonal rhabdomyosarcoma (botryoid type) of the vagina. 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