{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:37:10Z","timestamp":1778701030394,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n            Introduction\u2003Necrotizing enterocolitis (NEC) is a devastating disease of infancy. Full-thickness bowel wall necrosis may lead to perforation, peritonitis, and death. Timeous clinical diagnosis of impending perforation is imperative.<\/jats:p><jats:p>\n            Objective\u2003The objective of this study was to determine whether a persistent tachycardia in an infant with proven NEC is indicative of full-thickness bowel wall necrosis and therefore impending perforation.<\/jats:p><jats:p>\n            Study Design\u2003This study was conducted at the University of Pretoria academic hospitals. Forty-five neonates with proven NEC were divided into a surgical group (32 progressed to full-thickness bowel necrosis) and a nonsurgical group (13 resolved on conservative treatment). Differences in the pulse rate between the groups were analyzed.<\/jats:p><jats:p>\n            Results\u2003The 24-hour leading average pulse rate data for the surgical group were analyzed over a period of 10 days leading up to surgery and compared with the nonsurgical group. A clear upward trend of the mean pulse rate was observed in the surgical group, 48 hours prior to surgery. This was statistically significant (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n            Conclusion\u2003This study demonstrated that a persistent tachycardia in a neonate with NEC is a predictor of progression to full-thickness bowel wall necrosis. Pulse rate is therefore an important clinical tool when deciding on operative management in NEC.<\/jats:p>","DOI":"10.1055\/s-0037-1615805","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T18:38:19Z","timestamp":1515004699000},"page":"774-778","source":"Crossref","is-referenced-by-count":4,"title":["Predictive Value of a Persistent Tachycardia to Indicate Impending Perforation in Necrotizing Enterocolitis"],"prefix":"10.1055","volume":"35","author":[{"given":"Jan","family":"Becker","sequence":"first","affiliation":[{"name":"Department of Surgery, Sefako Makgatho Health Sciences University, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"van der Schyff","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,3]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1615805.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T18:44:04Z","timestamp":1529347444000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1615805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2018,6,18]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1615805","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}