{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:55:09Z","timestamp":1769183709359,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases. Antenatal medical therapies that stimulate antenatal pulmonary development are therefore interesting alternatives. By presenting the animal research underpinning novel antenatal medical therapies for CDH, and considering the applications of these therapies to clinical practice, this review will explore the future of antenatal CDH management with a focus on the phosphodiesterase-5 inhibitor sildenafil.<\/jats:p>","DOI":"10.1055\/s-0037-1618603","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T23:38:52Z","timestamp":1516145932000},"page":"823-836","source":"Crossref","is-referenced-by-count":14,"title":["Antenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia"],"prefix":"10.1055","volume":"35","author":[{"given":"Aidan","family":"Kashyap","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"DeKoninck","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Crossley","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Thio","sequence":"first","affiliation":[{"name":"Newborn Research Centre, The Royal Women's Hospital, Melbourne, Australia"},{"name":"Centre of Research Excellence in Newborn Medicine, Murdoch Children's Research Institute, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia"},{"name":"PIPER \u2013 Neonatal Retrieval Services Victoria, The Royal Children's Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Polglase","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Russo","sequence":"first","affiliation":[{"name":"Division of Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Development and Regeneration, Cluster Woman and Child, Faculty of Medicine, KU Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Deprest","sequence":"first","affiliation":[{"name":"Division of Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Development and Regeneration, Cluster Woman and Child, Faculty of Medicine, KU Leuven, Belgium"},{"name":"Institute for Women's Health, University College London Hospital, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Hooper","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Hodges","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia"},{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia"},{"name":"Monash Women's Service, Monash Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,16]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1618603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T22:46:04Z","timestamp":1531176364000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1618603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2018,7,9]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1618603","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]}}}