{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:51:33Z","timestamp":1777521093514,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n            Background\u2003Patients with severe and moderate haemophilia A are treated prophylactically with factor VIII (FVIII) concentrate. Individualization of prophylaxis can be achieved by pharmacokinetic (PK)-guided dosing.<\/jats:p><jats:p>\n            Aim\u2003In this study, the performance of three PK tools (myPKFiT, Web-Accessible Population Pharmacokinetic Service-Hemophilia [WAPPS] and NONMEM) is compared.<\/jats:p><jats:p>\n            Methods\u2003In 39 patients, with severe or moderate haemophilia A, blood samples were collected 4, 24 and 48 hours after administration of 50 IU kg\u22121 of recombinant FVIII (Advate [n\u2009=\u200930] or Kogenate [n\u2009=\u20099]). FVIII dose, FVIII activity and patient characteristics were entered into the three PK tools. Obtained PK parameters and dosing advises were compared.<\/jats:p><jats:p>\n            Results\u2003myPKFiT provided PK parameters for 24 of 30 patients receiving Advate, whereas WAPPS and NONMEM provided estimates for all patients. Half-life was different among the three methods: medians were 12.6 hours (n\u2009=\u200924), 11.2 hours (n\u2009=\u200930) and 13.0 hours (n\u2009=\u200930) for myPKFiT, WAPPS and NONMEM (p\u2009&lt;\u20090.001), respectively. To maintain a FVIII trough level of 0.01 IU mL\u22121 after 48 hours, doses for myPKFiT and NONMEM were 15.1 and 11.0 IU kg\u22121 (p\u2009&lt;\u20090.01, n\u2009=\u200911) and for WAPPS and NONMEM were 9.0 and 8.0 IU kg\u22121 (p\u2009&lt;\u20090.01, n\u2009=\u200923), respectively. In nine patients receiving Kogenate, WAPPS and NONMEM produced different PK-parameter estimates; half-life was 15.0 and 12.3 hours and time to 0.05 IU mL\u22121 was 69.2 and 60.8 hours, respectively (p\u2009&lt;\u20090.01, n\u2009=\u20099). However, recommended doses to obtain these levels were not different.<\/jats:p><jats:p>\n            Conclusion\u2003The three evaluated PK tools produced different PK parameters and doses for recombinant FVIII. Haematologists should be aware that recommended doses may be influenced by the choice of PK tool.<\/jats:p>","DOI":"10.1055\/s-0038-1623531","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T19:15:22Z","timestamp":1540408522000},"page":"514-525","source":"Crossref","is-referenced-by-count":22,"title":["Cross-evaluation of Pharmacokinetic-Guided Dosing Tools for Factor VIII"],"prefix":"10.1055","volume":"118","author":[{"given":"T.","family":"Preijers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"van Moort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fijnvandraat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Leebeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cnossen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Math\u00f4t","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the \u2018OPTI-CLOT\u2019 Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,3,13]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1623531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:15:22Z","timestamp":1557173722000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1623531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,3,13]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1623531","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}