{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T09:33:14Z","timestamp":1648891994981},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The risk for developing heparin-induced thrombocytopenia in healthy individuals is thought to be low, but monitoring recommendations remain controversial. Therefore, a retrospective cohort study was conducted to identify the incidence of thrombocytopenic events in a healthy research population exposed and re-exposed to continuous intravenous (IV) unfractionated heparin. The Division of Sleep Medicine and the Centre for Clinical Investigations at Brigham and Women's Hospital, Boston, Massachusetts, United States, instituted a standardized platelet monitoring procedure for all research protocols that involved heparin to detect platelet count decreases. Protocol-related frequent blood sampling required use of continuous IV unfractionated heparin infusion (5,000 unit\/L in 0.45% saline at 40 mL\/h) to maintain line patency over extended periods of IV access. From the years 2009 to 2012, a total of 273 healthy volunteers enrolled in Sleep Medicine research protocols met study criteria as having been exposed and\/or re-exposed to continuously infused intravenous heparin for at least 4 hours. The mean continuous heparin exposure time was 88\u2009\u00b1\u200982 SD hours with a total of 397 heparin exposure and re-exposure events. Platelet count measurements were obtained on 629 occasions, representing a range from 2 to 9 draws per participant. No platelet count decrease of more than 50% was detected. There were no detected adverse bleeding or thrombotic events. In this retrospective study of healthy volunteers involved in a rigorously applied inpatient platelet monitoring protocol, heparin exposure and re-exposure did not lower platelet concentration and, therefore, does not appear to be associated with increased risk of HIT in this population.<\/jats:p>","DOI":"10.1055\/s-0038-1624565","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:44:09Z","timestamp":1517337849000},"page":"e49-e53","source":"Crossref","is-referenced-by-count":0,"title":["Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion"],"prefix":"10.1055","volume":"02","author":[{"given":"Jonathan","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Autori","sequence":"additional","affiliation":[{"name":"Center for Clinical Investigations, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Kidd","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northwestern Memorial Hospital, Chicago, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Connors","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Czeisler","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Scheuermaier","sequence":"additional","affiliation":[{"name":"Wits Sleep Laboratory, University of the Witwatersrand, Johannesburg, Braamfontein, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Duffy","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Klerman","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Scheer","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Kozak","sequence":"additional","affiliation":[{"name":"Center for Clinical Investigations, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Center for Clinical Investigations, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Goldhaber","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,30]]},"container-title":["TH Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1624565.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:48:47Z","timestamp":1557157727000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1624565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2018,1,8]]},"published-print":{"date-parts":[[2018,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1624565","relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}