{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:09:05Z","timestamp":1793855345159,"version":"4.6.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n            Objective\u2003This article describes the natural history of stage I twin\u2013twin transfusion syndrome (TTTS) including risk of progression to higher stage TTTS and pregnancy outcomes, and to identify risk factors for progression.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective cohort study of monochorionic diamniotic (MCDA) twin pregnancies from 2006 to 2016 with expectantly managed Quintero stage I TTTS.<\/jats:p><jats:p>\n            Results\u2003A total of 30 MCDA twin pregnancies with expectantly managed stage I TTTS were identified. Of these, eight (26.7%) progressed to higher stage TTTS. Median gestational age (GA) at diagnosis for those that progressed was 18.9\u2009\u00b1\u20092.9 weeks versus 21.4\u2009\u00b1\u20093.4 weeks in those that remained stable (p\u2009=\u20090.06). Presence of an arterioarterial (A-A) anastomosis was assessed for 20\/30 patients, and eight A-A were identified. Of those, 7\/8 (87.5%) remained stable. In the complete cohort, a tiny or transiently visible bladder was noted in seven donor twins. Of these, 4\/7 (57.1%) progressed. Excluding one termination, 47\/58 (81.0%) fetuses survived.<\/jats:p><jats:p>\n            Conclusion\u2003With expectant management of stage I TTTS, nearly three-fourths of pregnancies remain stable and most have survival of \u2265 1 twin. A-A anastomoses were not associated with progression to higher stage TTTS, whereas earlier GA at diagnosis or a small or intermittently visible donor bladder may herald greater risk of progression.<\/jats:p>","DOI":"10.1055\/s-0038-1627095","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T23:32:59Z","timestamp":1518132779000},"page":"1352-1357","source":"Crossref","is-referenced-by-count":12,"title":["Stage I Twin\u2013Twin Transfusion Syndrome: Outcomes of Expectant Management and Prognostic Features"],"prefix":"10.1055","volume":"35","author":[{"given":"Erin","family":"Washburn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Sparks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Gosnell","sequence":"additional","affiliation":[{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California"},{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Feldstein","sequence":"additional","affiliation":[{"name":"Fetal Treatment Center, University of California San Francisco, San Francisco, California"},{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,2,8]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1627095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:01:31Z","timestamp":1557172891000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1627095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":0,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2018,11,20]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1627095","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]}}}