{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:26:26Z","timestamp":1782152786513,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n            Background\u2003The aim of this study was to identify prognostic factors in patients affected by non-small cell lung cancer (NSCLC) with chest wall (CW) involvement, analyzing different strategies of treatment and surgical approaches.<\/jats:p><jats:p>\n            Methods\u2003Records of 59 patients affected by NSCLC with CW involvement underwent surgery were retrospectively reviewed, from January 2000 to March 2013.<\/jats:p><jats:p>\n            Results\u2003Induction therapy was administered to 18 (30.5%) patients while adjuvant treatment to 36 (61.0%). In 36 (61%) patients, lung resection was associated only with a parietal pleural resection while in 23 (39%) with CW en-bloc resection. Overall 5-year survival was 34%. Prognostic factors were evaluated in the 51 (86.4%) completely resected (R0) patients.<\/jats:p><jats:p>Five-year survival was 60% in patients undergoing induction therapy followed by surgery and 24% in those who underwent surgery as first treatment (p\u2009=\u20090.11). Five-year survival was better in the neoadjuvant group than that in the surgery group in IIB (T3N0) p-stage (100 vs 28%, p\u2009=\u20090.03), while in the IIIA (T3N1\u20132,T4N0) p-stage it was of 25 vs 0%, respectively (p\u2009=\u20090.53).<\/jats:p><jats:p>No 5-year survival difference was found in case of parietal pleural resection versus CW en-bloc resection (p\u2009=\u20090.27) and in case of only parietal pleural involvement versus soft tissue (p\u2009=\u20090.78).<\/jats:p><jats:p>In case of incomplete resection (R1), patients undergoing adjuvant radiotherapy had better 2-year survival than patients untreated: 60% vs 0% (p\u2009=\u20090.025).<\/jats:p><jats:p>\n            Conclusions\u2003Type of surgical resection and the deep of infiltration of disease do not influence survival in this subset of patients. Integrated treatments seem to be suitable: neoadjuvant therapies ensure a better survival rate than surgery alone in IIB and IIIA patients, instead adjuvant radiotherapy proves a fundamental option in incomplete resections.<\/jats:p>","DOI":"10.1055\/s-0038-1632363","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T18:39:16Z","timestamp":1520361556000},"page":"299-305","source":"Crossref","is-referenced-by-count":9,"title":["Non-Small Cell Lung Cancer with Chest Wall Involvement: Integrated Treatment or Surgery Alone?"],"prefix":"10.1055","volume":"67","author":[{"given":"Marco","family":"Chiappetta","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Nachira","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Congedo","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Meacci","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venanzio","family":"Porziella","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Margaritora","sequence":"additional","affiliation":[{"name":"Department Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,3,6]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1632363.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T18:46:15Z","timestamp":1559587575000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1632363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,6,3]]},"published-print":{"date-parts":[[2019,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1632363","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]}}}