{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:21:44Z","timestamp":1788520904574,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amer J Perinatol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n            Objective\u2003To determine if illness severity during the first days of life predicts adverse outcome in asphyxiated newborns treated with hypothermia.<\/jats:p><jats:p>\n            Study Design\u2003We conducted a retrospective cohort study of asphyxiated newborns treated with hypothermia. Illness severity was calculated daily during the first 4 days of life using the Score for Neonatal Acute Physiology II (SNAP-II score). Adverse outcome (death and\/or brain injury) was recorded. Differences in SNAP-II scores between the newborns with and without adverse outcome were assessed.<\/jats:p><jats:p>\n            Result\u2003214 newborns were treated with hypothermia. The average SNAP-II score over the first 4 days of life was significantly worse in newborns developing adverse outcome. The average SNAP-II score was an excellent predictor of death (area under the curve [AUC]: 0.93; p\u2009&lt;\u20090.001) and a fair predictor of adverse outcome (AUC: 0.73; p\u2009&lt;\u20090.001). The average SNAP-II score remained a significant predictor of adverse outcome (odds ratio [95% confidence interval]: 1.08 [1.04\u20131.12]; p\u2009&lt;\u20090.001), after adjusting for baseline characteristics, degree of initial asphyxial event, and initial severity of encephalopathy.<\/jats:p><jats:p>\n            Conclusion\u2003In asphyxiated newborns treated with hypothermia, not only the initial asphyxial event but also the illness severity during the first days of life was a significant predictor of death or brain injury.<\/jats:p>","DOI":"10.1055\/s-0038-1632368","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T18:54:36Z","timestamp":1518807276000},"page":"951-958","source":"Crossref","is-referenced-by-count":18,"title":["Illness Severity Predicts Death and Brain Injury in Asphyxiated Newborns Treated with Hypothermia"],"prefix":"10.1055","volume":"35","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Beltempo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Rampakakis","sequence":"first","affiliation":[{"name":"JSS Medical Research, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscille-Nice","family":"Sanon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Barbosa Vargas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Maluorni","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Saint-Martin","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,2,16]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1632368.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T05:33:50Z","timestamp":1532583230000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1632368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,7,25]]},"published-print":{"date-parts":[[2018,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1632368","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]}}}